David E. Gloriam

David E. Gloriam

Professor


  1. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Clausen, Rasmus P; Madsen, Ulf; Pedersen, Lars; Jimenez, Hermogenes N; Nielsen, Søren M; Mathiesen, Jesper M; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 82, No. 5, 2012, p. 929-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. E-pub ahead of print

    Pharmacology and function of the orphan GPR139 G protein-coupled receptor. / Vedel, Line; Nøhr, Anne Cathrine; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Basic & Clinical Pharmacology & Toxicology, 27.05.2019.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Present perspectives on the automated classification of the G-protein coupled receptors (GPCRs) at the protein sequence level. / Davies, Matthew N; Gloriam, David E; Secker, Andrew; Freitas, Alex A.; Timmis, Jon; Flower, Darren R.

    In: Current Topics in Medicinal Chemistry, Vol. 11, No. 15, 2011, p. 1994-2009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Probing the Existence of a Metastable Binding Site at the β2-Adrenergic Receptor with Homobivalent Bitopic Ligands. / Gaiser, Birgit I; Danielsen, Mia; Marcher-Rørsted, Emil; Røpke Jørgensen, Kira; Wróbel, Tomasz M; Frykman, Mikael; Johansson, Henrik; Bräuner-Osborne, Hans; Gloriam, David E; Mathiesen, Jesper Mosolff; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 62, No. 17, 12.09.2019, p. 7806-7839.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. ProteomeBinders : planning a European resource of affinity reagents for analysis of the human proteome. / Taussig, Michael J; Stoevesandt, Oda; Borrebaeck, Carl A K; Bradbury, Andrew R; Cahill, Dolores; Cambillau, Christian; de Daruvar, Antoine; Dübel, Stefan; Eichler, Jutta; Frank, Ronald; Gibson, Toby J; Gloriam, David E.; Gold, Larry; Herberg, Friedrich W; Hermjakob, Henning; Hoheisel, Jörg D; Joos, Thomas O; Kallioniemi, Olli; Koegl, Manfred; Koegll, Manfred; Konthur, Zoltán; Korn, Bernhard; Kremmer, Elisabeth; Krobitsch, Sylvia; Landegren, Ulf; van der Maarel, Silvère; McCafferty, John; Muyldermans, Serge; Nygren, Per-Ake; Palcy, Sandrine; Plückthun, Andreas; Polic, Bojan; Przybylski, Michael; Saviranta, Petri; Sawyer, Alan; Sherman, David J; Skerra, Arne; Templin, Markus; Ueffing, Marius; Uhlén, Mathias.

    In: Nature Methods, Vol. 4, No. 1, 01.2007, p. 13-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Proteomic applications of automated GPCR classification. / Davies, Matthew N; Gloriam, David E.; Secker, Andrew; Freitas, Alex A; Mendao, Miguel; Timmis, Jon; Flower, Darren R.

    In: Proteomics, Vol. 7, No. 16, 08.2007, p. 2800-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity. / Malfacini, Davide; Patt, Julian; Annala, Suvi; Harpsøe, Kasper; Eryilmaz, Funda; Reher, Raphael; Crüsemann, Max; Hanke, Wiebke; Zhang, Hang; Tietze, Daniel; Gloriam, David E; Bräuner-Osborne, Hans; Strømgaard, Kristian; König, Gabriele M; Inoue, Asuka; Gomeza, Jesus; Kostenis, Evi.

    In: The Journal of Biological Chemistry, Vol. 294, No. 15, 12.04.2019, p. 5747-5758.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Receptor selectivity between the G proteins Gα 12 and Gα 13 is defined by a single leucine-to-isoleucine variation. / Mackenzie, Amanda E.; Quon, Tezz; Lin, Li Chiung; Hauser, Alexander S.; Jenkins, Laura; Inoue, Asuka; Tobin, Andrew B.; Gloriam, David E.; Hudson, Brian D.; Milligan, Graeme.

    In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, No. 4, 01.04.2019, p. 5005-5017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    SMARTCyp : A 2D method for prediction of cytochrome P450-mediated drug metabolism. / Rydberg, Patrik ; Gloriam, David Erik Immanuel; Zaretzki, Jed; Breneman, Curt; Olsen, Lars.

    In: ACS Medicinal Chemistry Letters, Vol. 1, No. 3, 15.03.2010, p. 96-100.

    Research output: Contribution to journalLetterResearchpeer-review

  10. Published
    SMARTCyp web service. Rydberg, Patrik (Developer); Gloriam, David E. (Developer); Olsen, Lars (Developer). 2010. København : Det Farmaceutiske Fakultet.

    Research output: Non-textual formInteractive productionResearch

  11. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Selectivity determinants of GPCR-G-protein binding. / Flock, Tilman; Hauser, Alexander S; Lund, Nadia; Gloriam, David E; Balaji, Santhanam; Babu, M Madan.

    In: Nature, Vol. 545, No. 7654, 18.05.2017, p. 317-322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. / Fredriksson, Robert; Höglund, Pär J; Gloriam, David E.; Lagerström, Malin C; Schiöth, Helgi B.

    In: F E B S Letters, Vol. 554, No. 3, 20.11.2003, p. 381-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structural Mapping of Adenosine Receptor Mutations : Ligand Binding and Signaling Mechanisms. / Jespers, Willem; Schiedel, Anke C; Heitman, Laura H; Cooke, Robert M; Kleene, Lisa; van Westen, Gerard J P; Gloriam, David E; Müller, Christa E; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo.

    In: Trends in Pharmacological Sciences, Vol. 39, No. 1, 01.2018, p. 75-89.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators. / Chalikiopoulos, Alexander; Thiele, Stefanie; Malmgaard-Clausen, Mikkel; Rydberg, Patrik; Isberg, Vignir; Ulven, Trond; Frimurer, Thomas M; Rosenkilde, Mette M; Gloriam, David E.

    In: Journal of Chemical Information and Modeling, Vol. 53, No. 11, 25.11.2013, p. 2863-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators. / Kaae, Birgitte H; Harpsøe, Kasper; Kvist, Trine; Mathiesen, Jesper M; Mølck, Christina; Gloriam, David E; Jimenez, Hermogenes N; Uberti, Michelle A; Nielsen, Søren M; Nielsen, Birgitte; Bräuner-Osborne, Hans; Sauerberg, Per; Clausen, Rasmus Prætorius; Madsen, Ulf.

    In: ChemMedChem, Vol. 7, No. 3, 2012, p. 440-451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors. / Isberg, Vignir; Paine, James; Leth-Petersen, Sebastian; Kristensen, Jesper Langgaard; Gloriam, David E.

    In: P L o S One, Vol. 8, No. 11, e78515, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. The G protein-coupled receptor subset of the chicken genome. / Lagerström, Malin C; Hellström, Anders R; Gloriam, David E.; Larsson, Thomas P; Schiöth, Helgi B; Fredriksson, Robert.

    In: P L o S Computational Biology (Online), Vol. 2, No. 6, 02.06.2006, p. e54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. / Haitina, Tatjana; Fredriksson, Robert; Foord, Steven M; Schiöth, Helgi B; Gloriam, David E.

    In: B M C Genomics, Vol. 10, 2009, p. 24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. The G protein-coupled receptor subset of the rat genome. / Gloriam, David E.; Fredriksson, Robert; Schiöth, Helgi B.

    In: B M C Genomics, Vol. 8, 2007, p. 338.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    The SMARTCyp cytochrome P450 metabolism prediction server. / Rydberg, Patrik; Gloriam, David Erik Immanuel; Olsen, Lars.

    In: Bioinformatics, Vol. 26, No. 23, 01.12.2010, p. 2988-2989.

    Research output: Contribution to journalLetterResearchpeer-review

ID: 5953796