David E. Gloriam

David E. Gloriam

Professor


  1. Published

    mGluR5 : Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Mathiesen, Jesper M; Nielsen, Søren M; Bräuner-Osborne, Hans.

    In: Neurochemical Research, Vol. 39, No. 10, 10.2014, p. 1862-1875.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Trends in GPCR drug discovery: new agents, targets and indications. / Hauser, Alexander Sebastian; Gloriam, David E.; Attwood, Misty M.; Rask-Andersen, Mathias ; Schiöth, Helgi B. .

    In: Nature Reviews. Drug Discovery, Vol. 16, 178, 27.10.2017, p. 829-842.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 2016, p. 1035-1041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. / Fredriksson, Robert; Gloriam, David E.; Höglund, Pär J; Lagerström, Malin C; Schiöth, Helgi B.

    In: Biochemical and Biophysical Research Communications, Vol. 301, No. 3, 14.02.2003, p. 725-34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The repertoire of trace amine G-protein-coupled receptors : large expansion in zebrafish. / Gloriam, David E.; Bjarnadóttir, Thóra K; Yan, Yi-Lin; Postlethwait, John H; Schiöth, Helgi B; Fredriksson, Robert.

    In: Molecular Phylogenetics and Evolution, Vol. 35, No. 2, 05.2005, p. 470-82.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The orphan G protein-coupled receptor GPR139 is activated by the peptides : Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. / Jensen, Anne Cathrine Nøhr; Shehata, Mohamed A; Hauser, Alexander S; Isberg, Vignir; Mokrosinski, Jacek; Farooqi, I Sadaf; Pedersen, Daniel Sejer; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Neurochemistry International, Vol. 102, 01.01.2017, p. 105-113.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. / Bjarnadóttir, Thóra K; Fredriksson, Robert; Höglund, Pär J; Gloriam, David E.; Lagerström, Malin C; Schiöth, Helgi B.

    In: Genomics, Vol. 84, No. 1, 07.2004, p. 23-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The contribution of atom accessibility to site of metabolism models for cytochromes P450. / Rydberg, Patrik; Rostkowski, M.; Gloriam, D.E.; Olsen, L.

    In: Molecular Pharmaceutics, Vol. 10, No. 4, 01.04.2013, p. 1216-1223.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The SMARTCyp cytochrome P450 metabolism prediction server. / Rydberg, Patrik; Gloriam, David Erik Immanuel; Olsen, Lars.

    In: Bioinformatics, Vol. 26, No. 23, 01.12.2010, p. 2988-2989.

    Research output: Contribution to journalLetterResearchpeer-review

  10. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. The G protein-coupled receptor subset of the rat genome. / Gloriam, David E.; Fredriksson, Robert; Schiöth, Helgi B.

    In: B M C Genomics, Vol. 8, 2007, p. 338.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents. / Haitina, Tatjana; Fredriksson, Robert; Foord, Steven M; Schiöth, Helgi B; Gloriam, David E.

    In: B M C Genomics, Vol. 10, 2009, p. 24.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. The G protein-coupled receptor subset of the chicken genome. / Lagerström, Malin C; Hellström, Anders R; Gloriam, David E.; Larsson, Thomas P; Schiöth, Helgi B; Fredriksson, Robert.

    In: P L o S Computational Biology (Online), Vol. 2, No. 6, 02.06.2006, p. e54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Structure-activity relationships of constrained phenylethylamine ligands for the serotonin 5-ht2 receptors. / Isberg, Vignir; Paine, James; Leth-Petersen, Sebastian; Kristensen, Jesper Langgaard; Gloriam, David E.

    In: P L o S One, Vol. 8, No. 11, e78515, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Structure-activity relationships for negative allosteric mGluR5 modulators. / Kaae, Birgitte H; Harpsøe, Kasper; Kvist, Trine; Mathiesen, Jesper M; Mølck, Christina; Gloriam, David E; Jimenez, Hermogenes N; Uberti, Michelle A; Nielsen, Søren M; Nielsen, Birgitte; Bräuner-Osborne, Hans; Sauerberg, Per; Clausen, Rasmus Prætorius; Madsen, Ulf.

    In: ChemMedChem, Vol. 7, No. 3, 2012, p. 440-451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structure-Activity Relationships and Identification of Optmized CC-Chemokine Receptor CCR1, 5, and 8 Metal-Ion Chelators. / Chalikiopoulos, Alexander; Thiele, Stefanie; Malmgaard-Clausen, Mikkel; Rydberg, Patrik; Isberg, Vignir; Ulven, Trond; Frimurer, Thomas M; Rosenkilde, Mette M; Gloriam, David E.

    In: Journal of Chemical Information and Modeling, Vol. 53, No. 11, 25.11.2013, p. 2863-73.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Structural insight to mutation effects uncover a common allosteric site in class C GPCRs. / Harpsøe, Kasper; Boesgaard, Michael W; Munk, Christian; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Bioinformatics (Oxford, England), Vol. 33, No. 8, btw784, 2017, p. 1116-1120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structural Mapping of Adenosine Receptor Mutations : Ligand Binding and Signaling Mechanisms. / Jespers, Willem; Schiedel, Anke C; Heitman, Laura H; Cooke, Robert M; Kleene, Lisa; van Westen, Gerard J P; Gloriam, David E; Müller, Christa E; Sotelo, Eddy; Gutiérrez-de-Terán, Hugo.

    In: Trends in Pharmacological Sciences, Vol. 39, No. 1, 01.2018, p. 75-89.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. / Fredriksson, Robert; Höglund, Pär J; Gloriam, David E.; Lagerström, Malin C; Schiöth, Helgi B.

    In: F E B S Letters, Vol. 554, No. 3, 20.11.2003, p. 381-8.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Selectivity determinants of GPCR-G-protein binding. / Flock, Tilman; Hauser, Alexander S; Lund, Nadia; Gloriam, David E; Balaji, Santhanam; Babu, M Madan.

    In: Nature, Vol. 545, No. 7654, 18.05.2017, p. 317-322.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants. / Harpsøe, Kasper; Isberg, Vignir; Tehan, Benjamin G; Weiss, Dahlia; Arsova, Angela; Marshall, Fiona H; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 5, 13869, 11.09.2015, p. 1-11.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold. / Johansson, Henrik; Boesgaard, Michael Worch; Nørskov-Lauritsen, Lenea; Larsen, Inna; Kuhne, Sebastiaan; Gloriam, David E; Bräuner-Osborne, Hans; Sejer Pedersen, Daniel.

    In: Journal of Medicinal Chemistry, Vol. 58, No. 22, 25.11.2015, p. 8938-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published
    SMARTCyp web service. Rydberg, Patrik (Developer); Gloriam, David E. (Developer); Olsen, Lars (Developer). 2010. København : Det Farmaceutiske Fakultet.

    Research output: Non-textual formInteractive productionResearch

  25. Published

    SMARTCyp : A 2D method for prediction of cytochrome P450-mediated drug metabolism. / Rydberg, Patrik ; Gloriam, David Erik Immanuel; Zaretzki, Jed; Breneman, Curt; Olsen, Lars.

    In: ACS Medicinal Chemistry Letters, Vol. 1, No. 3, 15.03.2010, p. 96-100.

    Research output: Contribution to journalLetterResearchpeer-review

Previous 1 2 3 4 Next

ID: 5953796