David E. Gloriam

David E. Gloriam

Professor


  1. Published

    GPCRDB : an information system for G protein-coupled receptors. / Ísberg, Vignir; Vroling, Bas; van der Kant, Rob; Li, Kang; Vriend, Gert; Gloriam, David.

    In: Nucleic Acids Research, Vol. 42, No. Database issue, 01.2014, p. D422-D425.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    G protein- and agonist-bound serotonin 5-HT2A receptor model activated by steered molecular dynamics simulations. / Ísberg, Vignir; Balle, Thomas; Sander, Tommy; Jørgensen, Flemming Steen; Gloriam, David Erik Immanuel.

    In: Journal of Chemical Information and Modeling, Vol. 51, No. 2, 28.02.2011, p. 315-325.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Computer-aided discovery of aromatic L-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139. / Ísberg, Vignir; Andersen, Kirsten Bayer; Bisig, Christoph; Dietz, Gunnar Ph; Bräuner-Osborne, Hans; Gloriam, David Erik.

    In: Journal of Chemical Information and Modeling, Vol. 54, No. 6, 14.05.2014, p. 1553-1557.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Structure–activity relationship and conformational studies of the natural product cyclic depsipeptides YM-254890 and FR900359. / Zhang, Hang; Nielsen, Alexander L.; Boesgaard, Michael W.; Harpsøe, Kasper; Daly, Norelle L.; Xiong, Xiao-feng; Underwood, Christina R.; Haugaard-kedström, Linda M.; Bräuner-osborne, Hans; Gloriam, David E.; Strømgaard, Kristian.

    In: European Journal of Medicinal Chemistry, Vol. 156, 05.08.2018, p. 847-860.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. / Xiong, Xiaofeng; Zhang, Hang; Underwood, Christina R.; Harpsøe, Kasper; Gardella, Thomas J.; Wöldike, Mie F.; Mannstadt, Michael; Gloriam, David E.; Bräuner-osborne, Hans; Strømgaard, Kristian.

    In: Nature Chemistry, Vol. 8, No. 11, 2016, p. 1035-1041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. E-pub ahead of print

    Pharmacology and function of the orphan GPR139 G protein-coupled receptor. / Vedel, Line; Nøhr, Anne Cathrine; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Basic & Clinical Pharmacology & Toxicology, 27.05.2019.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    A Structural Framework for GPCR Chemogenomics : What’s In a Residue Number? / Vass, Márton; Kooistra, Albert J.; Verhoeven, Stefan; Gloriam, David; de Esch, Iwan J.P.; de Graaf, Chris.

    Methods in Molecular Biology. Humana Press, 2018. p. 73-113 (Methods in Molecular Biology, Vol. 1705).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  8. Published

    Modulation in selectivity and allosteric properties of small-molecule ligands for CC-chemokine receptors. / Thiele, Stefanie; Malmgaard-Clausen, Mikkel; Engel-Andreasen, Jens; Steen, Anne; Rummel, Pia C; Nielsen, Mads C; Gloriam, David E.; Frimurer, Thomas Michael; Ulven, Trond; Rosenkilde, Mette.

    In: Journal of Medicinal Chemistry, Vol. 55, No. 18, 27.09.2012, p. 8164-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Editorial overview : New technologies: GPCR drug design and function-exploiting the current (of) structures. / Tautermann, Christofer S; Gloriam, David E.

    In: Current Opinion in Pharmacology, Vol. 30, 02.08.2016, p. 7-10.

    Research output: Contribution to journalComment/debateResearch

  10. ProteomeBinders : planning a European resource of affinity reagents for analysis of the human proteome. / Taussig, Michael J; Stoevesandt, Oda; Borrebaeck, Carl A K; Bradbury, Andrew R; Cahill, Dolores; Cambillau, Christian; de Daruvar, Antoine; Dübel, Stefan; Eichler, Jutta; Frank, Ronald; Gibson, Toby J; Gloriam, David E.; Gold, Larry; Herberg, Friedrich W; Hermjakob, Henning; Hoheisel, Jörg D; Joos, Thomas O; Kallioniemi, Olli; Koegl, Manfred; Koegll, Manfred; Konthur, Zoltán; Korn, Bernhard; Kremmer, Elisabeth; Krobitsch, Sylvia; Landegren, Ulf; van der Maarel, Silvère; McCafferty, John; Muyldermans, Serge; Nygren, Per-Ake; Palcy, Sandrine; Plückthun, Andreas; Polic, Bojan; Przybylski, Michael; Saviranta, Petri; Sawyer, Alan; Sherman, David J; Skerra, Arne; Templin, Markus; Ueffing, Marius; Uhlén, Mathias.

    In: Nature Methods, Vol. 4, No. 1, 01.2007, p. 13-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site. / Shehata, Mohamed A.; Jensen, Anne Cathrine Nøhr; Jespers, Willem; Floryan, Leonard; Isberg, Vignir; Andersen, Kirsten Bayer; Åqvist, Johan; Gutiérrez-de-Terán, Hugo; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 7, 1128, 25.04.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Identification of the first surrogate agonists for the G protein-coupled receptor GPR132. / Shehata, Mohamed A.; Christensen, Hanna Belcik; Isberg, Vignir; Pedersen, Daniel Sejer; Bender, Andreas; Bräuner-Osborne, Hans; Gloriam, David E.

    In: RSC Advances, Vol. 5, 2015, p. 48551-48557.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139. / Shehata, Mohamed A; Jensen, Anne Cathrine Nøhr; Lissa, Delphine; Bisig, Christoph; Isberg, Vignir; Andersen, Kirsten B; Harpsøe, Kasper; Björkling, Fredrik; Bräuner-Osborne, Hans; Gloriam, David E.

    In: Scientific Reports, Vol. 6, 36681, 10.11.2016, p. 1-13.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    SMARTCyp : A 2D method for prediction of cytochrome P450-mediated drug metabolism. / Rydberg, Patrik ; Gloriam, David Erik Immanuel; Zaretzki, Jed; Breneman, Curt; Olsen, Lars.

    In: ACS Medicinal Chemistry Letters, Vol. 1, No. 3, 15.03.2010, p. 96-100.

    Research output: Contribution to journalLetterResearchpeer-review

  15. Published

    The SMARTCyp cytochrome P450 metabolism prediction server. / Rydberg, Patrik; Gloriam, David Erik Immanuel; Olsen, Lars.

    In: Bioinformatics, Vol. 26, No. 23, 01.12.2010, p. 2988-2989.

    Research output: Contribution to journalLetterResearchpeer-review

  16. Published

    The contribution of atom accessibility to site of metabolism models for cytochromes P450. / Rydberg, Patrik; Rostkowski, M.; Gloriam, D.E.; Olsen, L.

    In: Molecular Pharmaceutics, Vol. 10, No. 4, 01.04.2013, p. 1216-1223.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published
    SMARTCyp web service. Rydberg, Patrik (Developer); Gloriam, David E. (Developer); Olsen, Lars (Developer). 2010. København : Det Farmaceutiske Fakultet.

    Research output: Non-textual formInteractive productionResearch

  18. Published

    GPCRdb in 2018 : adding GPCR structure models and ligands. / Pándy-Szekeres, Gáspár; Munk, Christian; Tsonkov, Tsonko M; Mordalski, Stefan; Harpsøe, Kasper; Hauser, Alexander S; Bojarski, Andrzej J; Gloriam, David E.

    In: Nucleic Acids Research, Vol. 46, No. D1, gkx1109, 2018.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. / Peng, Yao; McCorvy, John D.; Harpsøe, Kasper; Lansu, Katherine; Yuan, Shuguang; Popov, Petr; Qu, Lu; Pu, Mengchen; Che, Tao; Nikolajsen, Louise F.; Huang, Xi-ping; Wu, Yiran; Shen, Ling; Bjørn-Yoshimoto, Walden E.; Ding, Kang; Wacker, Daniel; Han, Gye Won; Cheng, Jianjun; Katritch, Vsevolod; Jensen, Anders A.; Hanson, Michael A.; Zhao, Suwen; Gloriam, David E.; Roth, Bryan L.; Stevens, Raymond C.; Liu, Zhi-jie.

    In: Cell, Vol. 172, No. 4, P719-730.E14, 2018, p. 719-730.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Identification of a novel scaffold for a small molecule GPR139 receptor agonist. / Nøhr, Anne Cathrine; Shehata, Mohamed A; Palmer, Daniel; Pokhrel, Rina; Vallianou, Maria; Foster, Simon R; Gentry, Patrick R; Gloriam, David E; Bräuner-Osborne, Hans.

    In: Scientific Reports, Vol. 9, No. 1, 07.03.2019, p. 3802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Critical evaluation of the FANTOM3 non-coding RNA transcripts. / Nordström, Karl J V; Mirza, Majd A I; Almén, Markus Sällman; Gloriam, David Erik Immanuel; Fredriksson, Robert; Schiöth, Helgi B.

    In: Genomics, Vol. 94, No. 3, 2009, p. 169-176.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Comprehensive comparisons of the current human, mouse, and rat RefSeq, Ensembl, EST, and FANTOM3 datasets : identification of new human genes with specific tissue expression profile. / Nordström, Karl J V; Mirza, Majd A I; Larsson, Thomas P; Gloriam, David E.; Fredriksson, Robert; Schiöth, Helgi B.

    In: Biochemical and Biophysical Research Communications, Vol. 348, No. 3, 29.09.2006, p. 1063-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Clausen, Rasmus P; Madsen, Ulf; Pedersen, Lars; Jimenez, Hermogenes N; Nielsen, Søren M; Mathiesen, Jesper M; Bräuner-Osborne, Hans.

    In: Molecular Pharmacology, Vol. 82, No. 5, 2012, p. 929-37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    mGluR5 : Exploration of Orthosteric and Allosteric Ligand Binding Pockets and Their Applications to Drug Discovery. / Mølck, Christina; Harpsøe, Kasper; Gloriam, David E; Mathiesen, Jesper M; Nielsen, Søren M; Bräuner-Osborne, Hans.

    In: Neurochemical Research, Vol. 39, No. 10, 10.2014, p. 1862-1875.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Integrating structural and mutagenesis data to elucidate GPCR ligand binding. / Munk, Christian; Harpsøe, Kasper; Hauser, Alexander S; Isberg, Vignir; Gloriam, David E.

    In: Current Opinion in Pharmacology, Vol. 30, 10.2016, p. 51-58.

    Research output: Contribution to journalJournal articleResearchpeer-review

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