Nordsjællands Hospital - Hillerød, Dyrehavevej 29, 3400 Hillerød
Research area: Diabetes with special emphasis on hypoglycaemia
Clinical and experimental studies of hypoglycaemia in patients with type 1 diabetes and insulin-treated type 2 diabetes have been conducted to understand the mechanisms of development of severe hypoglycaemia. Our main result is the finding of a strong association between the genetically determined basal activity in the renin angiotensin system (RAS) and the risk of severe hypoglycaemia in patients with type 1 diabetes. The finding makes further understanding of the mechanisms of development of severe hypoglycaemia possible, makes prediction of individual risk of hypoglycaemia more precise, and may potentially make medical prevention of severe hypoglycaemia possible. The finding has initiated a series of experimental studies in normal subjects and patients with type 1 diabetes, who have been subjected to insulin-induced mild hypoglycaemia using neurophysiological and neuropsychological methods and imaging techniques.