Ultrastructural immunocytochemical localization of chondroitin sulfate proteoglycan in Bruch's membrane of the rat.

Research output: Contribution to journalJournal articleResearchpeer-review

W L Lin, E Essner, K J McCarthy, J R Couchman

Two monoclonal antibodies (Mab 4D5 and 2D6) raised against the core protein of a basement membrane chondroitin sulfate proteoglycan from Reichert's membrane of the rat, were used for ultrastructural immunoperoxidase localization of this protein in Bruch's membrane of the rat. Immunoreactivity for both antibodies was found in the basal lamina (basement membrane) of the choriocapillary endothelium and retinal pigment epithelium, in collagen fibers in the collagenous zones, and surrounding the elastic layer.
Original languageEnglish
JournalInvestigative Ophthalmology & Visual Science
Volume33
Issue number6
Pages (from-to)2072-5
Number of pages3
ISSN0146-0404
Publication statusPublished - 1992

Bibliographical note

Keywords: Animals; Antibodies, Monoclonal; Basement Membrane; Bruch Membrane; Capillaries; Chondroitin Sulfates; Choroid; Female; Immunoenzyme Techniques; Microscopy, Immunoelectron; Pigment Epithelium of Eye; Proteoglycans; Rats; Rats, Inbred Lew

ID: 5165934