The role of DNA base excision repair in brain homeostasis and disease

Research output: Contribution to journalJournal articleResearchpeer-review

Mansour Akbari, Marya Morevati, Deborah Croteau, Vilhelm A Bohr

Chemical modification and spontaneous loss of nucleotide bases from DNA are estimated to occur at the rate of thousands per human cell per day. DNA base excision repair (BER) is a critical mechanism for repairing such lesions in nuclear and mitochondrial DNA. Defective expression or function of proteins required for BER or proteins that regulate BER have been consistently associated with neurological dysfunction and disease in humans. Recent studies suggest that DNA lesions in the nuclear and mitochondrial compartments and the cellular response to those lesions have a profound effect on cellular energy homeostasis, mitochondrial function and cellular bioenergetics, with especially strong influence on neurological function. Further studies in this area could lead to novel approaches to prevent and treat human neurodegenerative disease.

Original languageEnglish
JournalDNA Repair
Volume32
Pages (from-to)172-9
Number of pages8
ISSN1568-7864
DOIs
Publication statusPublished - Aug 2015

ID: 138764331