The effect of fatty acid positioning in dietary triacylglycerols and intake of long-chain n-3 polyunsaturated fatty acids on bone mineral accretion in growing piglets

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Anders Daniel Andersen, Stine E Ludvig, Camilla Trab Damsgaard, Pasi Pulkkinen, Mikko Finnilä, Huiling Mu, Thomas Thymann, Kim F. Michaelsen, Christian Mølgaard, Lotte Lauritzen

Long-chain n-3 PUFA (LCPUFA) and palmitate (16:0) positioning in the triacylglycerol (TAG) of infant formula may affect calcium-uptake which could affect bone health. We investigated if a human milk fat substitute (HMFS) with a modified TAG structure holding 16:0 predominantly in the sn-2-position compared with a control (CONT) and if increasing n-3LCPUFA intake giving fish oil (FO) compared with sunflower oil (SO) would affect bone parameters in piglets in two sets of controlled 14d-interventions (n=12/group). We assessed this by dual-energy x-ray absorptiometry, and ex vivo peripheral quantitative computed tomography and mechanical strength. Bone mineral content (BMC) was higher in the FO compared to the SO-group (p=0.03). Despite similar weight gain in HMFS- and CONT-groups, body fat accumulation was higher with HMFS (p
Original languageEnglish
JournalProstaglandins, Leukotrienes & Essential Fatty Acids
Issue number4
Pages (from-to)235-240
Number of pages6
Publication statusPublished - 2013

ID: 49148218