The Carcinogenic Agent Azoxymethane (AOM) Enhances Early Inflammation-induced Colon Crypt Pathology

Research output: Contribution to journalJournal articleResearchpeer-review

Freja Albjerg Venning, Mogens Helweg Claesson, Hannelouise Kissow







Severe combined immunodeficiency (SCID) mice transplanted with CD4+ T cells depleted of CD25+ regulatory T cells develop colitis within 2-3 weeks after the T cell transfer. In the present study we studied the effect of the carcinogen azoxymethane (AOM) on the colon crypt pathology of normal SCID mice and SCID mice with transfer colitis. AOM by itself did result in neither weight loss nor inflammation although treatment affected crypt widths and numbers. Although AOM together with T cell transfer did not increase the level of gut inflammation including COX-2 expression, AOM increased crypt changes associated with colon inflammation such as a decline in crypt numbers and an increase in crypts width throughout the large intestine. Thus it appears that AOM lower the threshold level for inflammation-induced changes which potentially may lead to neoplasia.
Original languageEnglish
JournalJournal of Cancer Science & Therapy
Volume5
Issue number11
Pages (from-to)377-383
Number of pages7
ISSN1948-5956
DOIs
Publication statusPublished - 2013

ID: 91450447