Syndecans-2 and -4; close cousins, but not identical twins.

Research output: Contribution to journalJournal articleResearchpeer-review

Eok-Soo Oh, John R Couchman

The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.
Original languageEnglish
JournalMolecules and Cells
Volume17
Issue number2
Pages (from-to)181-7
Number of pages6
ISSN1016-8478
Publication statusPublished - 2004

Bibliographical note

Keywords: Animals; Cell Adhesion; Cell Division; Cytoskeleton; Growth Substances; Humans; Membrane Glycoproteins; Neovascularization, Physiologic; Protein Conformation; Proteoglycans; Syndecan-2; Syndecan-4; Tissue Distribution

ID: 5160964