Syndecans: synergistic activators of cell adhesion.

Research output: Contribution to journalJournal articleResearchpeer-review

A Woods, J R Couchman

Cell-surface proteoglycans participate in cell adhesion, growth-factor signalling, lipase activity and anticoagulation. Until recently, only the roles of the glycosaminoglycan chains were investigated. Now, with molecular characterization of several core proteins, the roles of each individual proteoglycan species in cellular signalling pathways are being determined. This review describes some of the recent advances in our understanding of the major transmembrane group of heparan sulfate proteoglycans, the syndecans, including evidence that they play an important role as accessory signalling molecules modulating integrin-based adhesion.
Original languageEnglish
JournalTrends in Cell Biolology
Volume8
Issue number5
Pages (from-to)189-92
Number of pages3
ISSN0962-8924
Publication statusPublished - 1998

Bibliographical note

Keywords: Amino Acid Sequence; Animals; Cell Adhesion; Cell Communication; Drug Synergism; Humans; Membrane Glycoproteins; Molecular Sequence Data; Proteoglycans; Signal Transduction; Syndecans

ID: 5164513