Syndecan-4 and focal adhesion function.

Research output: Contribution to journalJournal articleResearchpeer-review

A Woods, J R Couchman

Two groups have now reported the viability of mice that lack syndecan-4. These mice have wound healing/angiogenesis problems, and fibroblasts from these animals differ in adhesion and migration from normal. This is consistent with recent in vitro data indicating a need for signaling via syndecan-4 for focal adhesion formation, and reports that overexpression of proteins that bind syndecan-4 can modify cell adhesion and migration.
Original languageEnglish
JournalCurrent Opinion in Cell Biology
Volume13
Issue number5
Pages (from-to)578-83
Number of pages5
ISSN0955-0674
Publication statusPublished - 2001

Bibliographical note

Keywords: Animals; Focal Adhesions; Integrins; Membrane Glycoproteins; Mice; Mice, Knockout; Models, Biological; Neovascularization, Pathologic; Protein Structure, Tertiary; Proteoglycans; Signal Transduction; Syndecan-4; Wound Healing

ID: 5162938