Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases

Research output: Contribution to journalJournal articleResearchpeer-review

Hooi Ching Lim, John Robert Couchman

While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.
Original languageEnglish
JournalBBA General Subjects
Volume1840
Issue number8
Pages (from-to)2482–2490
Number of pages9
ISSN0304-4165
DOIs
Publication statusPublished - 18 Jan 2014

ID: 109872808