Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases
Research output: Contribution to journal › Journal article › Research › peer-review
Hooi Ching Lim, John Robert Couchman
While syndecan-2 is usually considered a mesenchymal transmembrane proteoglycan, it can be upregulated in some tumour cells, such as the malignant breast carcinoma cell line, MDA-MB231. Depletion of this syndecan by siRNA, but not other syndecans, has a marked effect on cell morphology, increasing spreading, microfilament bundle and focal adhesion formation, with reduced cell migration.
|Journal||BBA General Subjects|
|Number of pages||9|
|Publication status||Published - 18 Jan 2014|