Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma
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Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. / Lendorf, Maria E; Manon-Jensen, Tina; Kronqvist, Pauliina; Multhaupt, Hinke A B; Couchman, John R.
In: Journal of Histochemistry and Cytochemistry, Vol. 59, No. 6, 01.06.2011, p. 615-29.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma
AU - Lendorf, Maria E
AU - Manon-Jensen, Tina
AU - Kronqvist, Pauliina
AU - Multhaupt, Hinke A B
AU - Couchman, John R
PY - 2011/6/1
Y1 - 2011/6/1
N2 - Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p
AB - Syndecan proteoglycans may be key regulators of tumor invasion and metastasis because this four-member family of transmembrane receptors regulates cell adhesion, proliferation, and differentiation. Their expression can also serve as prognostic markers. In breast carcinomas, syndecan-1 overexpression correlates with poor prognosis and aggressive phenotype. Syndecan-4 is expressed in most breast carcinoma cell lines, but its role in malignancy is unclear. A possible relationship between syndecan-1 and syndecan-4 expression and established prognostic factors in breast carcinomas was examined. Duplicate samples of 114 benign and malignant breast disease cases were stained for the two syndecans. Clinicopathological information was available for all cases. Syndecan-1 was detected in 72.8% of cases, with significant association between its expression and histological tumor type (p
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Female
KW - Fluorescent Antibody Technique
KW - Humans
KW - Immunohistochemistry
KW - Middle Aged
KW - Syndecan-1
KW - Syndecan-4
KW - Tumor Markers, Biological
KW - Young Adult
U2 - 10.1369/0022155411405057
DO - 10.1369/0022155411405057
M3 - Journal article
C2 - 21430259
VL - 59
SP - 615
EP - 629
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
SN - 0022-1554
IS - 6
ER -
ID: 33789003