Syndecan proteoglycan contributions to cytoskeletal organization and contractility

Research output: Contribution to journalJournal articleResearchpeer-review

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Syndecan proteoglycan contributions to cytoskeletal organization and contractility. / Okina, E; Manon-Jensen, T; Whiteford, J R; Couchman, J R.

In: Scandinavian Journal of Medicine & Science in Sports Online, 2009.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Okina, E, Manon-Jensen, T, Whiteford, JR & Couchman, JR 2009, 'Syndecan proteoglycan contributions to cytoskeletal organization and contractility', Scandinavian Journal of Medicine & Science in Sports Online. https://doi.org/10.1111/j.1600-0838.2009.00941.x

APA

Okina, E., Manon-Jensen, T., Whiteford, J. R., & Couchman, J. R. (2009). Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scandinavian Journal of Medicine & Science in Sports Online. https://doi.org/10.1111/j.1600-0838.2009.00941.x

Vancouver

Okina E, Manon-Jensen T, Whiteford JR, Couchman JR. Syndecan proteoglycan contributions to cytoskeletal organization and contractility. Scandinavian Journal of Medicine & Science in Sports Online. 2009. https://doi.org/10.1111/j.1600-0838.2009.00941.x

Author

Okina, E ; Manon-Jensen, T ; Whiteford, J R ; Couchman, J R. / Syndecan proteoglycan contributions to cytoskeletal organization and contractility. In: Scandinavian Journal of Medicine & Science in Sports Online. 2009.

Bibtex

@article{97cc5e80625c11de8bc9000ea68e967b,
title = "Syndecan proteoglycan contributions to cytoskeletal organization and contractility",
abstract = "Cells exert tension on the extracellular matrix through specific receptors that link to the actin cytoskeleton. The best characterized are the integrins, which, when activated and clustered, can link to the extracellular matrix at specialized adhesion zones, known as focal contacts or focal adhesions. However, other transmembrane receptors can also localize there, including one transmembrane proteoglycan, syndecan-4. This heparan sulfate proteoglycan can also link directly to the cytoskeleton through alpha-actinin, and can signal through protein kinase C. In turn, the pathway leads to RhoA and Rho kinases that control actomyosin contractility. Syndecan-4 may, therefore, be a sensor of tension exerted on the matrix. These processes are described here, their significance being potential roles in wound contraction, tumor-stroma interactions, fibrosis and the regulation of motility.",
author = "E Okina and T Manon-Jensen and Whiteford, {J R} and Couchman, {J R}",
year = "2009",
doi = "10.1111/j.1600-0838.2009.00941.x",
language = "English",
journal = "Scandinavian Journal of Medicine & Science in Sports",
issn = "0905-7188",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Syndecan proteoglycan contributions to cytoskeletal organization and contractility

AU - Okina, E

AU - Manon-Jensen, T

AU - Whiteford, J R

AU - Couchman, J R

PY - 2009

Y1 - 2009

N2 - Cells exert tension on the extracellular matrix through specific receptors that link to the actin cytoskeleton. The best characterized are the integrins, which, when activated and clustered, can link to the extracellular matrix at specialized adhesion zones, known as focal contacts or focal adhesions. However, other transmembrane receptors can also localize there, including one transmembrane proteoglycan, syndecan-4. This heparan sulfate proteoglycan can also link directly to the cytoskeleton through alpha-actinin, and can signal through protein kinase C. In turn, the pathway leads to RhoA and Rho kinases that control actomyosin contractility. Syndecan-4 may, therefore, be a sensor of tension exerted on the matrix. These processes are described here, their significance being potential roles in wound contraction, tumor-stroma interactions, fibrosis and the regulation of motility.

AB - Cells exert tension on the extracellular matrix through specific receptors that link to the actin cytoskeleton. The best characterized are the integrins, which, when activated and clustered, can link to the extracellular matrix at specialized adhesion zones, known as focal contacts or focal adhesions. However, other transmembrane receptors can also localize there, including one transmembrane proteoglycan, syndecan-4. This heparan sulfate proteoglycan can also link directly to the cytoskeleton through alpha-actinin, and can signal through protein kinase C. In turn, the pathway leads to RhoA and Rho kinases that control actomyosin contractility. Syndecan-4 may, therefore, be a sensor of tension exerted on the matrix. These processes are described here, their significance being potential roles in wound contraction, tumor-stroma interactions, fibrosis and the regulation of motility.

U2 - 10.1111/j.1600-0838.2009.00941.x

DO - 10.1111/j.1600-0838.2009.00941.x

M3 - Journal article

JO - Scandinavian Journal of Medicine & Science in Sports

JF - Scandinavian Journal of Medicine & Science in Sports

SN - 0905-7188

ER -

ID: 12866329