Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death
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Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death. / Weischer, Maren; Bojesen, Stig E; Cawthon, Richard M; Freiberg, Jacob J; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 32, 2012, p. 822-29.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death
AU - Weischer, Maren
AU - Bojesen, Stig E
AU - Cawthon, Richard M
AU - Freiberg, Jacob J
AU - Tybjærg-Hansen, Anne
AU - Nordestgaard, Børge G
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. METHODS AND RESULTS: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n=929), ischemic heart disease (n=2038), and death (n=4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies (P=7×10(-74) to P=3×10(-125)). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01-1.19) for myocardial infarction, 1.06 (1.00-1.11) for ischemic heart disease, and 1.09 (1.05-1.13) for early death per 1000-base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07-2.07) for myocardial infarction, 1.24 (1.01-1.53) for ischemic heart disease, and 1.25 (1.07-1.46) for early death. CONCLUSIONS: Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death.
AB - OBJECTIVE: We tested the hypothesis that short telomere length is associated with increased risk of myocardial infarction, ischemic heart disease, and early death. METHODS AND RESULTS: We measured leukocyte telomere length in 2 prospective studies of 19 838 Danish general population participants from the Copenhagen City Heart Study and the Copenhagen General Population Study. Participants were followed for up to 19 years for incident myocardial infarction (n=929), ischemic heart disease (n=2038), and death (n=4342). Follow-up was 100% complete. Telomere length decreased linearly with increasing age in women and men in both studies (P=7×10(-74) to P=3×10(-125)). Multifactorially adjusted hazard ratios were 1.10 (95% CI 1.01-1.19) for myocardial infarction, 1.06 (1.00-1.11) for ischemic heart disease, and 1.09 (1.05-1.13) for early death per 1000-base pair decrease in telomere length. The multifactorially adjusted hazard ratios for the shortest versus the longest decile of telomere length were 1.49 (1.07-2.07) for myocardial infarction, 1.24 (1.01-1.53) for ischemic heart disease, and 1.25 (1.07-1.46) for early death. CONCLUSIONS: Short telomere length is associated with only modestly increased risk of myocardial infarction, ischemic heart disease, and early death.
U2 - 10.1161/ATVBAHA.111.237271
DO - 10.1161/ATVBAHA.111.237271
M3 - Journal article
C2 - 22199369
VL - 32
SP - 822
EP - 829
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
ER -
ID: 40184585