Sarcopenia, Aging and Prospective Interventional Strategies

Research output: Contribution to journalReviewResearchpeer-review

Tyler B Waltz, Elayne M Fivenson, Marya Morevati, Chuanhao Li, Kevin G Becker, Vilhelm A Bohr, Evandro F Fang

Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondrial function in muscle should be considered. Many naturally-occurring compounds, derived from commonly consumed foods, possess anti-sarcopenic effects, such asnicotinamide riboside, tomatidine, and Urolithin A. These naturally-occurring compounds can improve mitochondrial health and efficiency by modulating mitochondrial biogenesis, cellular stress resistance, or mitophagy. Further research should assess whether compounds that improve mitochondrial health can attenuate sarcopenia in humans.

Original languageEnglish
JournalCurrent Medicinal Chemistry
Volume25
Issue number40
Pages (from-to)5588-5596
Number of pages9
ISSN0929-8673
DOIs
Publication statusPublished - 2018

ID: 213241620