Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Hiroko P. Indo, Clare L Hawkins, Ikuo Nakanishi, Ken-Ichiro Matsumoto, Hirofumi Matsui, Shigeaki Suenaga, Michael J Davies, Daret K St Clair, Toshihiko Ozawa, Hideyuki J. Majima

Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death.

Original languageEnglish
Title of host publicationPharmacology of Mitochondria
Number of pages18
Volume240
PublisherSpringer
Publication date2017
Pages439-456
ISBN (Print)978-3-319-57311-3
ISBN (Electronic)978-3-319-57313-7
DOIs
Publication statusPublished - 2017
SeriesHandbook of Experimental Pharmacology
Volume240
ISSN0171-2004

    Research areas

  • Journal Article

ID: 182331246