Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans.

Research output: Contribution to journalJournal articleResearchpeer-review

Atsuko Yoneda, John R Couchman

Syndecans, a family of transmembrane proteoglycans, interact with numerous extracellular ligands through specific sequences in their heparan sulfate chains and have been considered to be co-receptors for matrix molecules and growth factors. In addition to their roles as co-receptors, many studies have recently suggested that signaling through core protein of syndecans can regulate cytoskeletal organization through their clustering, association with cytoskeletal structures, binding to cytoplasmic binding proteins, and intracellular phosphorylation. Here we will review current understanding of signaling through syndecans in cytoskeletal organization.
Original languageEnglish
JournalMatrix Biology
Volume22
Issue number1
Pages (from-to)25-33
Number of pages8
ISSN0945-053X
Publication statusPublished - 2003

Bibliographical note

Keywords: Actins; Amino Acid Sequence; Animals; Cytoskeleton; Focal Adhesions; Humans; Integrins; Membrane Glycoproteins; Molecular Sequence Data; Neurites; Proteoglycans; Syndecans

ID: 5162655