Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

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Zaklina Kovacevic, Sumit Sahni, K.H. Lok, M J Davies, D A Wink, Des R Richardson

We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

Original languageEnglish
JournalB B A - Reviews on Cancer
Volume1861
Issue number5 Pt A
Pages (from-to)995-999
Number of pages5
ISSN0006-3002
DOIs
Publication statusPublished - May 2017

    Research areas

  • Journal Article, Review

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