Potassium channels in the heart

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

Potassium channels in the heart. / Thomsen, Morten Bækgaard.

Channelopathies in Heart Disease. ed. / Dierk Thomas ; Carol Ann Remme. Springer, 2018. p. 47-75 (Cardiac and Vascular Biology, Vol. 6).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Thomsen, MB 2018, Potassium channels in the heart. in D Thomas & CA Remme (eds), Channelopathies in Heart Disease. Springer, Cardiac and Vascular Biology, vol. 6, pp. 47-75. https://doi.org/10.1007/978-3-319-77812-9_3

APA

Thomsen, M. B. (2018). Potassium channels in the heart. In D. Thomas , & C. A. Remme (Eds.), Channelopathies in Heart Disease (pp. 47-75). Springer. Cardiac and Vascular Biology Vol. 6 https://doi.org/10.1007/978-3-319-77812-9_3

Vancouver

Thomsen MB. Potassium channels in the heart. In Thomas D, Remme CA, editors, Channelopathies in Heart Disease. Springer. 2018. p. 47-75. (Cardiac and Vascular Biology, Vol. 6). https://doi.org/10.1007/978-3-319-77812-9_3

Author

Thomsen, Morten Bækgaard. / Potassium channels in the heart. Channelopathies in Heart Disease. editor / Dierk Thomas ; Carol Ann Remme. Springer, 2018. pp. 47-75 (Cardiac and Vascular Biology, Vol. 6).

Bibtex

@inbook{70535519f44046c5a421f2d44d262eee,

title = "Potassium channels in the heart",

abstract = "Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.",

author = "Thomsen, {Morten B{\ae}kgaard}",

note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",

year = "2018",

doi = "10.1007/978-3-319-77812-9_3",

language = "English",

isbn = "978-3-319-77811-2",

series = "Cardiac and Vascular Biology",

publisher = "Springer",

pages = "47--75",

editor = "{Thomas }, {Dierk } and Remme, {Carol Ann }",

booktitle = "Channelopathies in Heart Disease",

address = "Switzerland",

}

RIS

TY - CHAP

T1 - Potassium channels in the heart

AU - Thomsen, Morten Bækgaard

PY - 2018

Y1 - 2018

N2 - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

AB - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

U2 - 10.1007/978-3-319-77812-9_3

DO - 10.1007/978-3-319-77812-9_3

M3 - Book chapter

AN - SCOPUS:85102585634

SN - 978-3-319-77811-2

T3 - Cardiac and Vascular Biology

SP - 47

EP - 75

BT - Channelopathies in Heart Disease

A2 - Thomas , Dierk

A2 - Remme, Carol Ann

PB - Springer

ER -

ID: 210151234