Oxidation and modification of extracellular matrix and its role in disease
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Oxidation and modification of extracellular matrix and its role in disease. / Chuang, C Y; Degendorfer, G; Davies, Michael Jonathan.
In: Free Radical Research, Vol. 48, No. 9, 09.2014, p. 970-89.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oxidation and modification of extracellular matrix and its role in disease
AU - Chuang, C Y
AU - Degendorfer, G
AU - Davies, Michael Jonathan
PY - 2014/9
Y1 - 2014/9
N2 - There is accumulating evidence that damage to extracellular materials and particularly the extracellular matrix, can play a major role in multiple human pathologies. In contrast to cells, the extracellular compartment of most biological tissues is relatively poorly equipped to prevent or repair damage caused by oxidation due to lower levels of antioxidant defenses (low molecular mass and enzymatic) and repair systems (both catabolic and enzymatic). The extracellular compartment is therefore likely to be subject to both an increased extent of damage and an overall accumulation of damage due to slow turnover and/or poor repair. The nature and consequences of damage to the extracellular matrix is poorly understood, despite evidence that changes in matrix structure influences not only structural integrity, but also cell adhesion, proliferation, migration and signaling, and cytokine and growth factor binding. In this article the nature of the extracellular matrix is briefly reviewed, together with evidence for the presence of matrix modifications in cardiovascular disease. The oxidants and mechanisms that are known to damage extracellular matrix are reviewed, together with the limited data available to date on how such changes affect structural properties and cellular behavior.
AB - There is accumulating evidence that damage to extracellular materials and particularly the extracellular matrix, can play a major role in multiple human pathologies. In contrast to cells, the extracellular compartment of most biological tissues is relatively poorly equipped to prevent or repair damage caused by oxidation due to lower levels of antioxidant defenses (low molecular mass and enzymatic) and repair systems (both catabolic and enzymatic). The extracellular compartment is therefore likely to be subject to both an increased extent of damage and an overall accumulation of damage due to slow turnover and/or poor repair. The nature and consequences of damage to the extracellular matrix is poorly understood, despite evidence that changes in matrix structure influences not only structural integrity, but also cell adhesion, proliferation, migration and signaling, and cytokine and growth factor binding. In this article the nature of the extracellular matrix is briefly reviewed, together with evidence for the presence of matrix modifications in cardiovascular disease. The oxidants and mechanisms that are known to damage extracellular matrix are reviewed, together with the limited data available to date on how such changes affect structural properties and cellular behavior.
U2 - 10.3109/10715762.2014.920087
DO - 10.3109/10715762.2014.920087
M3 - Journal article
C2 - 24796988
VL - 48
SP - 970
EP - 989
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 9
ER -
ID: 128973462