Nuclear DNA damage signalling to mitochondria in ageing

Research output: Contribution to journalJournal articleResearchpeer-review

Evandro Fei Fang, Morten Scheibye-Knudsen, Katrin F Chua, Mark P Mattson, Deborah L Croteau, Vilhelm A Bohr

Mitochondrial dysfunction is a hallmark of ageing, and mitochondrial maintenance may lead to increased healthspan. Emerging evidence suggests a crucial role for signalling from the nucleus to mitochondria (NM signalling) in regulating mitochondrial function and ageing. An important initiator of NM signalling is nuclear DNA damage, which accumulates with age and may contribute to the development of age-associated diseases. DNA damage-dependent NM signalling constitutes a network that includes nuclear sirtuins and controls genomic stability and mitochondrial integrity. Pharmacological modulation of NM signalling is a promising novel approach for the prevention and treatment of age-associated diseases.

Original languageEnglish
JournalNature Reviews. Molecular Cell Biology
Volume17
Issue number5
Pages (from-to)308-321
Number of pages14
ISSN1471-0072
DOIs
Publication statusPublished - May 2016
Externally publishedYes

ID: 172127641