Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

Research output: Contribution to journalJournal articleResearchpeer-review

Ernst Malle, Gunther Marsche, Jürgen Arnhold, Michael Jonathan Davies

Substantial evidence supports the notion that oxidative processes contribute to the pathogenesis of atherosclerosis and coronary heart disease. The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, detected in human atherosclerotic lesions are, however, unclear, with multiple species having been invoked. Over the last few years, considerable data have been obtained in support of the hypothesis that oxidants generated by the heme enzyme myeloperoxidase play a key role in oxidation reactions in the artery wall. In this article, the evidence for a role of myeloperoxidase, and oxidants generated therefrom, in the modification of low-density lipoprotein, the major source of lipids in atherosclerotic lesions, is reviewed. Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation, respectively.

Original languageEnglish
JournalB B A - Reviews on Cancer
Volume1761
Issue number4
Pages (from-to)392-415
Number of pages24
ISSN0006-3002
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

    Research areas

  • Animals, Apolipoprotein B-100, Apolipoproteins B, Atherosclerosis, Humans, Hypochlorous Acid, Lipid Peroxidation, Lipoproteins, LDL, Oxidants, Oxidation-Reduction, Peroxidase

ID: 129671531