Mitochondria in the signaling pathways that control longevity and health span

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Mitochondria in the signaling pathways that control longevity and health span. / Akbari, Mansour; Kirkwood, Thomas B L; Bohr, Vilhelm A.

In: Ageing Research Reviews, Vol. 54, 100940, 2019.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Akbari, M, Kirkwood, TBL & Bohr, VA 2019, 'Mitochondria in the signaling pathways that control longevity and health span', Ageing Research Reviews, vol. 54, 100940. https://doi.org/10.1016/j.arr.2019.100940

APA

Akbari, M., Kirkwood, T. B. L., & Bohr, V. A. (2019). Mitochondria in the signaling pathways that control longevity and health span. Ageing Research Reviews, 54, [100940]. https://doi.org/10.1016/j.arr.2019.100940

Vancouver

Akbari M, Kirkwood TBL, Bohr VA. Mitochondria in the signaling pathways that control longevity and health span. Ageing Research Reviews. 2019;54. 100940. https://doi.org/10.1016/j.arr.2019.100940

Author

Akbari, Mansour ; Kirkwood, Thomas B L ; Bohr, Vilhelm A. / Mitochondria in the signaling pathways that control longevity and health span. In: Ageing Research Reviews. 2019 ; Vol. 54.

Bibtex

@article{3b132d8e1a314a70b567d53ae1f9ff4f,

title = "Mitochondria in the signaling pathways that control longevity and health span",

abstract = "Genetic and pharmacological intervention studies have identified evolutionarily conserved and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, and genome damage response signaling pathways, as prominent regulators of longevity and health span in various species. Mitochondria are the primary sites of ATP production and key players in several other important cellular processes. Mitochondrial dysfunction diminishes tissue and organ functional performance and is a commonly considered feature of the aging process. Here we review the evidence that through reciprocal and multilevel functional interactions, mitochondria are implicated in the lifespan modulation function of these pathways, which altogether constitute a highly dynamic and complex system that controls the aging process. An important characteristic of these pathways is their extensive crosstalk and apparent malleability to modification by non-invasive pharmacological, dietary, and lifestyle interventions, with promising effects on lifespan and health span in animal models and potentially also in humans.",

author = "Mansour Akbari and Kirkwood, {Thomas B L} and Bohr, {Vilhelm A}",

note = "Copyright {\textcopyright} 2019. Published by Elsevier B.V.",

year = "2019",

doi = "10.1016/j.arr.2019.100940",

language = "English",

volume = "54",

journal = "Ageing Research Reviews",

issn = "1568-1637",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Mitochondria in the signaling pathways that control longevity and health span

AU - Akbari, Mansour

AU - Kirkwood, Thomas B L

AU - Bohr, Vilhelm A

PY - 2019

Y1 - 2019

N2 - Genetic and pharmacological intervention studies have identified evolutionarily conserved and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, and genome damage response signaling pathways, as prominent regulators of longevity and health span in various species. Mitochondria are the primary sites of ATP production and key players in several other important cellular processes. Mitochondrial dysfunction diminishes tissue and organ functional performance and is a commonly considered feature of the aging process. Here we review the evidence that through reciprocal and multilevel functional interactions, mitochondria are implicated in the lifespan modulation function of these pathways, which altogether constitute a highly dynamic and complex system that controls the aging process. An important characteristic of these pathways is their extensive crosstalk and apparent malleability to modification by non-invasive pharmacological, dietary, and lifestyle interventions, with promising effects on lifespan and health span in animal models and potentially also in humans.

AB - Genetic and pharmacological intervention studies have identified evolutionarily conserved and functionally interconnected networks of cellular energy homeostasis, nutrient-sensing, and genome damage response signaling pathways, as prominent regulators of longevity and health span in various species. Mitochondria are the primary sites of ATP production and key players in several other important cellular processes. Mitochondrial dysfunction diminishes tissue and organ functional performance and is a commonly considered feature of the aging process. Here we review the evidence that through reciprocal and multilevel functional interactions, mitochondria are implicated in the lifespan modulation function of these pathways, which altogether constitute a highly dynamic and complex system that controls the aging process. An important characteristic of these pathways is their extensive crosstalk and apparent malleability to modification by non-invasive pharmacological, dietary, and lifestyle interventions, with promising effects on lifespan and health span in animal models and potentially also in humans.

U2 - 10.1016/j.arr.2019.100940

DO - 10.1016/j.arr.2019.100940

M3 - Review

C2 - 31415807

VL - 54

JO - Ageing Research Reviews

JF - Ageing Research Reviews

SN - 1568-1637

M1 - 100940

ER -

ID: 225996393