Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes : findings from the Breast Cancer Association Consortium. / Broeks, Annegien; Schmidt, Marjanka K; Sherman, Mark E; Couch, Fergus J; Hopper, John L; Dite, Gillian S; Apicella, Carmel; Smith, Letitia D; Hammet, Fleur; Southey, Melissa C; Van 't Veer, Laura J; de Groot, Renate; Smit, Vincent T H B M; Fasching, Peter A; Beckmann, Matthias W; Jud, Sebastian; Ekici, Arif B; Hartmann, Arndt; Hein, Alexander; Schulz-Wendtland, Ruediger; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sinn, Hans-Peter; Sohn, Christof; Tchatchou, Sandrine; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Ørsted, David D; Kaur-Knudsen, Diljit; Milne, Roger L; Pérez, Jose I Arias; Zamora, Pilar; Rodríguez, Primitiva Menéndez; Benítez, Javier; Brauch, Hiltrud; Justenhoven, Christina; Ko, Yon-Dschun; Hamann, Ute; Fischer, Hans-Peter; Brüning, Thomas; Pesch, Beate; Chang-Claude, Jenny; Wang-Gohrke, Shan; Bremer, Michael; Karstens, Johann H; Hillemanns, Peter; Dörk, Thilo; Nevanlinna, Heli A; GENICA Network.

In: Human Molecular Genetics, Vol. 20, No. 16, 2011, p. 3289-303.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Broeks, A, Schmidt, MK, Sherman, ME, Couch, FJ, Hopper, JL, Dite, GS, Apicella, C, Smith, LD, Hammet, F, Southey, MC, Van 't Veer, LJ, de Groot, R, Smit, VTHBM, Fasching, PA, Beckmann, MW, Jud, S, Ekici, AB, Hartmann, A, Hein, A, Schulz-Wendtland, R, Burwinkel, B, Marme, F, Schneeweiss, A, Sinn, H-P, Sohn, C, Tchatchou, S, Bojesen, SE, Nordestgaard, BG, Flyger, H, Ørsted, DD, Kaur-Knudsen, D, Milne, RL, Pérez, JIA, Zamora, P, Rodríguez, PM, Benítez, J, Brauch, H, Justenhoven, C, Ko, Y-D, Hamann, U, Fischer, H-P, Brüning, T, Pesch, B, Chang-Claude, J, Wang-Gohrke, S, Bremer, M, Karstens, JH, Hillemanns, P, Dörk, T, Nevanlinna, HA & GENICA Network 2011, 'Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium', Human Molecular Genetics, vol. 20, no. 16, pp. 3289-303. https://doi.org/10.1093/hmg/ddr228

APA

Broeks, A., Schmidt, M. K., Sherman, M. E., Couch, F. J., Hopper, J. L., Dite, G. S., Apicella, C., Smith, L. D., Hammet, F., Southey, M. C., Van 't Veer, L. J., de Groot, R., Smit, V. T. H. B. M., Fasching, P. A., Beckmann, M. W., Jud, S., Ekici, A. B., Hartmann, A., Hein, A., ... GENICA Network (2011). Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Human Molecular Genetics, 20(16), 3289-303. https://doi.org/10.1093/hmg/ddr228

Vancouver

Broeks A, Schmidt MK, Sherman ME, Couch FJ, Hopper JL, Dite GS et al. Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium. Human Molecular Genetics. 2011;20(16):3289-303. https://doi.org/10.1093/hmg/ddr228

Author

Broeks, Annegien ; Schmidt, Marjanka K ; Sherman, Mark E ; Couch, Fergus J ; Hopper, John L ; Dite, Gillian S ; Apicella, Carmel ; Smith, Letitia D ; Hammet, Fleur ; Southey, Melissa C ; Van 't Veer, Laura J ; de Groot, Renate ; Smit, Vincent T H B M ; Fasching, Peter A ; Beckmann, Matthias W ; Jud, Sebastian ; Ekici, Arif B ; Hartmann, Arndt ; Hein, Alexander ; Schulz-Wendtland, Ruediger ; Burwinkel, Barbara ; Marme, Frederik ; Schneeweiss, Andreas ; Sinn, Hans-Peter ; Sohn, Christof ; Tchatchou, Sandrine ; Bojesen, Stig E ; Nordestgaard, Børge G ; Flyger, Henrik ; Ørsted, David D ; Kaur-Knudsen, Diljit ; Milne, Roger L ; Pérez, Jose I Arias ; Zamora, Pilar ; Rodríguez, Primitiva Menéndez ; Benítez, Javier ; Brauch, Hiltrud ; Justenhoven, Christina ; Ko, Yon-Dschun ; Hamann, Ute ; Fischer, Hans-Peter ; Brüning, Thomas ; Pesch, Beate ; Chang-Claude, Jenny ; Wang-Gohrke, Shan ; Bremer, Michael ; Karstens, Johann H ; Hillemanns, Peter ; Dörk, Thilo ; Nevanlinna, Heli A ; GENICA Network. / Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes : findings from the Breast Cancer Association Consortium. In: Human Molecular Genetics. 2011 ; Vol. 20, No. 16. pp. 3289-303.

Bibtex

@article{823cb5aa9cce4ec281dec2a359f903bf,
title = "Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium",
abstract = "Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER- tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (P-heterogeneity = 6.1 × 10(-18)), rs3803662 (16q12) (P = 3.7 × 10(-5)), rs13281615 (8q24) (P = 0.002), rs13387042 (2q35) (P = 0.006), rs4973768 (3p24) (P = 0.003) and rs6504950 (17q23) (P = 0.002). The two candidate loci, CASP8 (rs1045485, rs17468277) and TGFB1 (rs1982073), were most strongly related with the risk of PR negative tumors (P = 5.1 × 10(-6) and P = 4.1 × 10(-4), respectively), as previously suggested. Four of the eight loci identified in GWAS were associated with triple negative tumors (P = 0.016): rs3803662 (16q12), rs889312 (5q11), rs3817198 (11p15) and rs13387042 (2q35); however, only two of them (16q12 and 2q35) were associated with tumors with the core basal phenotype (P = 0.002). These analyses are consistent with different biological origins of breast cancers, and indicate that tumor stratification might help in the identification and characterization of novel risk factors for breast cancer subtypes. This may eventually result in further improvements in prevention, early detection and treatment.",
author = "Annegien Broeks and Schmidt, {Marjanka K} and Sherman, {Mark E} and Couch, {Fergus J} and Hopper, {John L} and Dite, {Gillian S} and Carmel Apicella and Smith, {Letitia D} and Fleur Hammet and Southey, {Melissa C} and {Van 't Veer}, {Laura J} and {de Groot}, Renate and Smit, {Vincent T H B M} and Fasching, {Peter A} and Beckmann, {Matthias W} and Sebastian Jud and Ekici, {Arif B} and Arndt Hartmann and Alexander Hein and Ruediger Schulz-Wendtland and Barbara Burwinkel and Frederik Marme and Andreas Schneeweiss and Hans-Peter Sinn and Christof Sohn and Sandrine Tchatchou and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Henrik Flyger and {\O}rsted, {David D} and Diljit Kaur-Knudsen and Milne, {Roger L} and P{\'e}rez, {Jose I Arias} and Pilar Zamora and Rodr{\'i}guez, {Primitiva Men{\'e}ndez} and Javier Ben{\'i}tez and Hiltrud Brauch and Christina Justenhoven and Yon-Dschun Ko and Ute Hamann and Hans-Peter Fischer and Thomas Br{\"u}ning and Beate Pesch and Jenny Chang-Claude and Shan Wang-Gohrke and Michael Bremer and Karstens, {Johann H} and Peter Hillemanns and Thilo D{\"o}rk and Nevanlinna, {Heli A} and B{\o}rge Nordestgaard",
year = "2011",
doi = "http://dx.doi.org/10.1093/hmg/ddr228",
language = "English",
volume = "20",
pages = "3289--303",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "16",

}

RIS

TY - JOUR

T1 - Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes

T2 - findings from the Breast Cancer Association Consortium

AU - Broeks, Annegien

AU - Schmidt, Marjanka K

AU - Sherman, Mark E

AU - Couch, Fergus J

AU - Hopper, John L

AU - Dite, Gillian S

AU - Apicella, Carmel

AU - Smith, Letitia D

AU - Hammet, Fleur

AU - Southey, Melissa C

AU - Van 't Veer, Laura J

AU - de Groot, Renate

AU - Smit, Vincent T H B M

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Jud, Sebastian

AU - Ekici, Arif B

AU - Hartmann, Arndt

AU - Hein, Alexander

AU - Schulz-Wendtland, Ruediger

AU - Burwinkel, Barbara

AU - Marme, Frederik

AU - Schneeweiss, Andreas

AU - Sinn, Hans-Peter

AU - Sohn, Christof

AU - Tchatchou, Sandrine

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Flyger, Henrik

AU - Ørsted, David D

AU - Kaur-Knudsen, Diljit

AU - Milne, Roger L

AU - Pérez, Jose I Arias

AU - Zamora, Pilar

AU - Rodríguez, Primitiva Menéndez

AU - Benítez, Javier

AU - Brauch, Hiltrud

AU - Justenhoven, Christina

AU - Ko, Yon-Dschun

AU - Hamann, Ute

AU - Fischer, Hans-Peter

AU - Brüning, Thomas

AU - Pesch, Beate

AU - Chang-Claude, Jenny

AU - Wang-Gohrke, Shan

AU - Bremer, Michael

AU - Karstens, Johann H

AU - Hillemanns, Peter

AU - Dörk, Thilo

AU - Nevanlinna, Heli A

AU - GENICA Network

PY - 2011

Y1 - 2011

N2 - Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER- tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (P-heterogeneity = 6.1 × 10(-18)), rs3803662 (16q12) (P = 3.7 × 10(-5)), rs13281615 (8q24) (P = 0.002), rs13387042 (2q35) (P = 0.006), rs4973768 (3p24) (P = 0.003) and rs6504950 (17q23) (P = 0.002). The two candidate loci, CASP8 (rs1045485, rs17468277) and TGFB1 (rs1982073), were most strongly related with the risk of PR negative tumors (P = 5.1 × 10(-6) and P = 4.1 × 10(-4), respectively), as previously suggested. Four of the eight loci identified in GWAS were associated with triple negative tumors (P = 0.016): rs3803662 (16q12), rs889312 (5q11), rs3817198 (11p15) and rs13387042 (2q35); however, only two of them (16q12 and 2q35) were associated with tumors with the core basal phenotype (P = 0.002). These analyses are consistent with different biological origins of breast cancers, and indicate that tumor stratification might help in the identification and characterization of novel risk factors for breast cancer subtypes. This may eventually result in further improvements in prevention, early detection and treatment.

AB - Breast cancers demonstrate substantial biological, clinical and etiological heterogeneity. We investigated breast cancer risk associations of eight susceptibility loci identified in GWAS and two putative susceptibility loci in candidate genes in relation to specific breast tumor subtypes. Subtypes were defined by five markers (ER, PR, HER2, CK5/6, EGFR) and other pathological and clinical features. Analyses included up to 30 040 invasive breast cancer cases and 53 692 controls from 31 studies within the Breast Cancer Association Consortium. We confirmed previous reports of stronger associations with ER+ than ER- tumors for six of the eight loci identified in GWAS: rs2981582 (10q26) (P-heterogeneity = 6.1 × 10(-18)), rs3803662 (16q12) (P = 3.7 × 10(-5)), rs13281615 (8q24) (P = 0.002), rs13387042 (2q35) (P = 0.006), rs4973768 (3p24) (P = 0.003) and rs6504950 (17q23) (P = 0.002). The two candidate loci, CASP8 (rs1045485, rs17468277) and TGFB1 (rs1982073), were most strongly related with the risk of PR negative tumors (P = 5.1 × 10(-6) and P = 4.1 × 10(-4), respectively), as previously suggested. Four of the eight loci identified in GWAS were associated with triple negative tumors (P = 0.016): rs3803662 (16q12), rs889312 (5q11), rs3817198 (11p15) and rs13387042 (2q35); however, only two of them (16q12 and 2q35) were associated with tumors with the core basal phenotype (P = 0.002). These analyses are consistent with different biological origins of breast cancers, and indicate that tumor stratification might help in the identification and characterization of novel risk factors for breast cancer subtypes. This may eventually result in further improvements in prevention, early detection and treatment.

U2 - http://dx.doi.org/10.1093/hmg/ddr228

DO - http://dx.doi.org/10.1093/hmg/ddr228

M3 - Journal article

VL - 20

SP - 3289

EP - 3303

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 16

ER -

ID: 40184344