Long-term effects on the progress of neuropathy after diabetic Charcot foot: an 8.5-year prospective case-control study
Research output: Contribution to journal › Journal article › Research › peer-review
- Long-term effects on the progress of neuropathy after diabetic Charcot foot
Final published version, 736 KB, PDF document
OBJECTIVE: Charcot foot is a severe complication to diabetes mellitus, associated with diabetic neuropathy. Any long-term effects of a Charcot foot on the progress of neuropathy are still largely unexplored. The objective was to investigate whether a previous Charcot foot had any long-term effects on the progress of neuropathy.
RESULTS: An 8.5-year follow-up case-control study of 49 individuals with diabetes mellitus, 24 of whom also had Charcot foot at baseline visit in 2005-2007. Neuropathy was assessed with a questionnaire, biothesiometry, heart rate variability and venous occlusion plethysmography. Of the 49 baseline participants, 22 were able to participate in the follow-up. Twelve had passed away in the meantime. Heart rate variability was unchanged in both groups; from 9.7 to 7.2 beats/min (p = 0.053) in the Charcot group, and 14.3 to 12.6 beats/min (p = 0.762) in the control group. Somato-sensoric neuropathy showed no difference between baseline and follow-up in the Charcot group (from 39.1 to 38.5 V) (p = 0.946), but a significantly worsened sensitivity in the control group (from 25.1 to 38.9 V) (p = 0.002). In conclusion, we found that any differences in somatic or cardial autonomic neuropathy present at baseline had disappeared at follow-up after 8.5 years.
|Journal||BMC Research Notes|
|Number of pages||6|
|Publication status||Published - 2018|
- Aged, Case-Control Studies, Diabetic Foot/physiopathology, Diabetic Nephropathies/physiopathology, Disease Progression, Female, Follow-Up Studies, Humans, Male, Middle Aged
Number of downloads are based on statistics from Google Scholar and www.ku.dk