Standard
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. / McKay, James D.; Hung, Rayjean J.; Han, Younghun; Zong, Xuchen; Carreras-Torres, Robert; Christiani, David C.; Caporaso, Neil E.; Johansson, Mattias; Xiao, Xiangjun; Li, Yafang; Byun, Jinyoung; Dunning, Alison; Pooley, Karen A.; Qian, David C.; Ji, Xuemei; Liu, Geoffrey; Timofeeva, Maria N.; Bojesen, Stig E.; Wu, Xifeng; Marchand, Loic Le; Albanes, Demetrios; Bickeböller, Heike; Aldrich, Melinda C.; Bush, William S.; Tardon, Adonina; Rennert, Gad; Teare, M. Dawn; Field, John K.; Kiemeney, Lambertus A.; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthew B.; Andrew, Angeline S.; Shen, Hongbing; Hong, Yun Chul; Yuan, Jian Min; Bertazzi, Pier Alberto; Pesatori, Angela C.; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob S.; Mellemgaard, Anders; Saliba, Walid; Haiman, Christopher A.; Wilkens, Lynne R.; SpiroMeta Consortium; Rafnar, Thorunn; Thorgeirsson, Thorgeir E; Reginsson, Gunnar W.; Brennan, Paul; Landi, Maria Teresa; Amos, Christopher I.
In:
Nature Genetics, Vol. 49, No. 7, 2017, p. 1126-1132.
Research output: Contribution to journal › Letter › Research › peer-review
Harvard
McKay, JD, Hung, RJ, Han, Y, Zong, X, Carreras-Torres, R, Christiani, DC, Caporaso, NE, Johansson, M, Xiao, X, Li, Y, Byun, J, Dunning, A, Pooley, KA, Qian, DC, Ji, X, Liu, G, Timofeeva, MN
, Bojesen, SE, Wu, X, Marchand, LL, Albanes, D, Bickeböller, H, Aldrich, MC, Bush, WS, Tardon, A, Rennert, G, Teare, MD, Field, JK, Kiemeney, LA, Lazarus, P, Haugen, A, Lam, S, Schabath, MB, Andrew, AS, Shen, H, Hong, YC, Yuan, JM, Bertazzi, PA, Pesatori, AC, Ye, Y, Diao, N, Su, L, Zhang, R, Brhane, Y, Leighl, N, Johansen, JS, Mellemgaard, A, Saliba, W, Haiman, CA, Wilkens, LR, SpiroMeta Consortium, Rafnar, T, Thorgeirsson, TE, Reginsson, GW, Brennan, P, Landi, MT & Amos, CI 2017, '
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes',
Nature Genetics, vol. 49, no. 7, pp. 1126-1132.
https://doi.org/10.1038/ng.3892APA
McKay, J. D., Hung, R. J., Han, Y., Zong, X., Carreras-Torres, R., Christiani, D. C., Caporaso, N. E., Johansson, M., Xiao, X., Li, Y., Byun, J., Dunning, A., Pooley, K. A., Qian, D. C., Ji, X., Liu, G., Timofeeva, M. N.
, Bojesen, S. E., Wu, X., ... Amos, C. I. (2017).
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Nature Genetics,
49(7), 1126-1132.
https://doi.org/10.1038/ng.3892Vancouver
McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC et al.
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
Nature Genetics. 2017;49(7):1126-1132.
https://doi.org/10.1038/ng.3892Author
McKay, James D. ; Hung, Rayjean J. ; Han, Younghun ; Zong, Xuchen ; Carreras-Torres, Robert ; Christiani, David C. ; Caporaso, Neil E. ; Johansson, Mattias ; Xiao, Xiangjun ; Li, Yafang ; Byun, Jinyoung ; Dunning, Alison ; Pooley, Karen A. ; Qian, David C. ; Ji, Xuemei ; Liu, Geoffrey ; Timofeeva, Maria N. ; Bojesen, Stig E. ; Wu, Xifeng ; Marchand, Loic Le ; Albanes, Demetrios ; Bickeböller, Heike ; Aldrich, Melinda C. ; Bush, William S. ; Tardon, Adonina ; Rennert, Gad ; Teare, M. Dawn ; Field, John K. ; Kiemeney, Lambertus A. ; Lazarus, Philip ; Haugen, Aage ; Lam, Stephen ; Schabath, Matthew B. ; Andrew, Angeline S. ; Shen, Hongbing ; Hong, Yun Chul ; Yuan, Jian Min ; Bertazzi, Pier Alberto ; Pesatori, Angela C. ; Ye, Yuanqing ; Diao, Nancy ; Su, Li ; Zhang, Ruyang ; Brhane, Yonathan ; Leighl, Natasha ; Johansen, Jakob S. ; Mellemgaard, Anders ; Saliba, Walid ; Haiman, Christopher A. ; Wilkens, Lynne R. ; SpiroMeta Consortium ; Rafnar, Thorunn ; Thorgeirsson, Thorgeir E ; Reginsson, Gunnar W. ; Brennan, Paul ; Landi, Maria Teresa ; Amos, Christopher I. / Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. In: Nature Genetics. 2017 ; Vol. 49, No. 7. pp. 1126-1132.
Bibtex
@article{a559f44716fe435e829bad02ac139fee,
title = "Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes",
abstract = "Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.",
author = "McKay, {James D.} and Hung, {Rayjean J.} and Younghun Han and Xuchen Zong and Robert Carreras-Torres and Christiani, {David C.} and Caporaso, {Neil E.} and Mattias Johansson and Xiangjun Xiao and Yafang Li and Jinyoung Byun and Alison Dunning and Pooley, {Karen A.} and Qian, {David C.} and Xuemei Ji and Geoffrey Liu and Timofeeva, {Maria N.} and Bojesen, {Stig E.} and Xifeng Wu and Marchand, {Loic Le} and Demetrios Albanes and Heike Bickeb{\"o}ller and Aldrich, {Melinda C.} and Bush, {William S.} and Adonina Tardon and Gad Rennert and Teare, {M. Dawn} and Field, {John K.} and Kiemeney, {Lambertus A.} and Philip Lazarus and Aage Haugen and Stephen Lam and Schabath, {Matthew B.} and Andrew, {Angeline S.} and Hongbing Shen and Hong, {Yun Chul} and Yuan, {Jian Min} and Bertazzi, {Pier Alberto} and Pesatori, {Angela C.} and Yuanqing Ye and Nancy Diao and Li Su and Ruyang Zhang and Yonathan Brhane and Natasha Leighl and Johansen, {Jakob S.} and Anders Mellemgaard and Walid Saliba and Haiman, {Christopher A.} and Wilkens, {Lynne R.} and {SpiroMeta Consortium} and Thorunn Rafnar and Thorgeirsson, {Thorgeir E} and Reginsson, {Gunnar W.} and Paul Brennan and Landi, {Maria Teresa} and Amos, {Christopher I}",
year = "2017",
doi = "10.1038/ng.3892",
language = "English",
volume = "49",
pages = "1126--1132",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "7",
}
RIS
TY - JOUR
T1 - Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
AU - McKay, James D.
AU - Hung, Rayjean J.
AU - Han, Younghun
AU - Zong, Xuchen
AU - Carreras-Torres, Robert
AU - Christiani, David C.
AU - Caporaso, Neil E.
AU - Johansson, Mattias
AU - Xiao, Xiangjun
AU - Li, Yafang
AU - Byun, Jinyoung
AU - Dunning, Alison
AU - Pooley, Karen A.
AU - Qian, David C.
AU - Ji, Xuemei
AU - Liu, Geoffrey
AU - Timofeeva, Maria N.
AU - Bojesen, Stig E.
AU - Wu, Xifeng
AU - Marchand, Loic Le
AU - Albanes, Demetrios
AU - Bickeböller, Heike
AU - Aldrich, Melinda C.
AU - Bush, William S.
AU - Tardon, Adonina
AU - Rennert, Gad
AU - Teare, M. Dawn
AU - Field, John K.
AU - Kiemeney, Lambertus A.
AU - Lazarus, Philip
AU - Haugen, Aage
AU - Lam, Stephen
AU - Schabath, Matthew B.
AU - Andrew, Angeline S.
AU - Shen, Hongbing
AU - Hong, Yun Chul
AU - Yuan, Jian Min
AU - Bertazzi, Pier Alberto
AU - Pesatori, Angela C.
AU - Ye, Yuanqing
AU - Diao, Nancy
AU - Su, Li
AU - Zhang, Ruyang
AU - Brhane, Yonathan
AU - Leighl, Natasha
AU - Johansen, Jakob S.
AU - Mellemgaard, Anders
AU - Saliba, Walid
AU - Haiman, Christopher A.
AU - Wilkens, Lynne R.
AU - SpiroMeta Consortium
AU - Rafnar, Thorunn
AU - Thorgeirsson, Thorgeir E
AU - Reginsson, Gunnar W.
AU - Brennan, Paul
AU - Landi, Maria Teresa
AU - Amos, Christopher I
PY - 2017
Y1 - 2017
N2 - Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
AB - Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
U2 - 10.1038/ng.3892
DO - 10.1038/ng.3892
M3 - Letter
C2 - 28604730
AN - SCOPUS:85020451435
VL - 49
SP - 1126
EP - 1132
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 7
ER -
