Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
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Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? / Hansen, Thomas Lau; Rasmussen, Lene Juel; Madsen, Claus Desler; Frederiksen, Jane Bruun; Espersen, Maiken Lise Marcker; Singh, Keshav K.
In: Journal of Aging Research, Vol. 2012, 2012, p. 192503.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
AU - Hansen, Thomas Lau
AU - Rasmussen, Lene Juel
AU - Madsen, Claus Desler
AU - Frederiksen, Jane Bruun
AU - Espersen, Maiken Lise Marcker
AU - Singh, Keshav K.
PY - 2012
Y1 - 2012
N2 - Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.
AB - Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.
U2 - 10.1155/2012/192503
DO - 10.1155/2012/192503
M3 - Journal article
C2 - 22720157
VL - 2012
SP - 192503
JO - Journal of Aging Research
JF - Journal of Aging Research
SN - 2090-2204
ER -
ID: 38379152