Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

Research output: Contribution to journalJournal article

Standard

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes. / Sabaratnam, Rugivan; Pedersen, Andreas J T; Kristensen, Jonas Møller; Handberg, Aase; Wojtaszewski, Jørgen; Højlund, Kurt.

In: Physiological Reports, Vol. 6, No. 12, e13723, 2018.

Research output: Contribution to journalJournal article

Harvard

Sabaratnam, R, Pedersen, AJT, Kristensen, JM, Handberg, A, Wojtaszewski, J & Højlund, K 2018, 'Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes', Physiological Reports, vol. 6, no. 12, e13723. https://doi.org/10.14814/phy2.13723

APA

Sabaratnam, R., Pedersen, A. J. T., Kristensen, J. M., Handberg, A., Wojtaszewski, J., & Højlund, K. (2018). Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes. Physiological Reports, 6(12), [e13723]. https://doi.org/10.14814/phy2.13723

Vancouver

Sabaratnam R, Pedersen AJT, Kristensen JM, Handberg A, Wojtaszewski J, Højlund K. Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes. Physiological Reports. 2018;6(12). e13723. https://doi.org/10.14814/phy2.13723

Author

Sabaratnam, Rugivan ; Pedersen, Andreas J T ; Kristensen, Jonas Møller ; Handberg, Aase ; Wojtaszewski, Jørgen ; Højlund, Kurt. / Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes. In: Physiological Reports. 2018 ; Vol. 6, No. 12.

Bibtex

@article{21bf30c6b8264e8cbf8eb2a5cb634e21,
title = "Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes",
abstract = "Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One-hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3-h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3-h into recovery. Plasma IL-6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL-15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3-h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight-matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.",
keywords = "Faculty of Science, Exercise resistance, Myokines, Skeletal muscle, T2D, Type 2 diabetes",
author = "Rugivan Sabaratnam and Pedersen, {Andreas J T} and Kristensen, {Jonas M{\o}ller} and Aase Handberg and J{\o}rgen Wojtaszewski and Kurt H{\o}jlund",
note = "CURIS 2018 NEXS 222",
year = "2018",
doi = "10.14814/phy2.13723",
language = "English",
volume = "6",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

AU - Sabaratnam, Rugivan

AU - Pedersen, Andreas J T

AU - Kristensen, Jonas Møller

AU - Handberg, Aase

AU - Wojtaszewski, Jørgen

AU - Højlund, Kurt

N1 - CURIS 2018 NEXS 222

PY - 2018

Y1 - 2018

N2 - Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One-hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3-h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3-h into recovery. Plasma IL-6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL-15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3-h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight-matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.

AB - Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One-hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3-h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3-h into recovery. Plasma IL-6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL-15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3-h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight-matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.

KW - Faculty of Science

KW - Exercise resistance

KW - Myokines

KW - Skeletal muscle

KW - T2D

KW - Type 2 diabetes

U2 - 10.14814/phy2.13723

DO - 10.14814/phy2.13723

M3 - Journal article

VL - 6

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 12

M1 - e13723

ER -

ID: 198597894