Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Research output: Contribution to journal › Review › Research › peer-review

Standard

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. / Theocharis, Achilleas D.; Skandalis, Spyros S.; Neill, Thomas; Multhaupt, Hinke A. B.; Hubo, Mario; Frey, Helena; Gopal, Sandeep; Gomes, Angelica; Afratis, Nikos; Lim, Hooi Ching; Couchman, John R.; Filmus, Jorge; Sanderson, Ralph D.; Schaefer, Liliana; Iozzo, Renato V.; Karamanos, Nikos K.

In: BBA Reviews on Cancer, Vol. 1855, No. 2, 04.2015, p. 276–300.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Theocharis, AD, Skandalis, SS, Neill, T, Multhaupt, HAB, Hubo, M, Frey, H, Gopal, S, Gomes, A, Afratis, N, Lim, HC, Couchman, JR, Filmus, J, Sanderson, RD, Schaefer, L, Iozzo, RV & Karamanos, NK 2015, 'Insights into the key roles of proteoglycans in breast cancer biology and translational medicine', BBA Reviews on Cancer, vol. 1855, no. 2, pp. 276–300. https://doi.org/10.1016/j.bbcan.2015.03.006

APA

Theocharis, A. D., Skandalis, S. S., Neill, T., Multhaupt, H. A. B., Hubo, M., Frey, H., Gopal, S., Gomes, A., Afratis, N., Lim, H. C., Couchman, J. R., Filmus, J., Sanderson, R. D., Schaefer, L., Iozzo, R. V., & Karamanos, N. K. (2015). Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. BBA Reviews on Cancer, 1855(2), 276–300. https://doi.org/10.1016/j.bbcan.2015.03.006

Vancouver

Theocharis AD, Skandalis SS, Neill T, Multhaupt HAB, Hubo M, Frey H et al. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. BBA Reviews on Cancer. 2015 Apr;1855(2):276–300. https://doi.org/10.1016/j.bbcan.2015.03.006

Author

Theocharis, Achilleas D. ; Skandalis, Spyros S. ; Neill, Thomas ; Multhaupt, Hinke A. B. ; Hubo, Mario ; Frey, Helena ; Gopal, Sandeep ; Gomes, Angelica ; Afratis, Nikos ; Lim, Hooi Ching ; Couchman, John R. ; Filmus, Jorge ; Sanderson, Ralph D. ; Schaefer, Liliana ; Iozzo, Renato V. ; Karamanos, Nikos K. / Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. In: BBA Reviews on Cancer. 2015 ; Vol. 1855, No. 2. pp. 276–300.

Bibtex

@article{2f1bf747e4ba403a9bf1a7e88f2e423e,
title = "Insights into the key roles of proteoglycans in breast cancer biology and translational medicine",
abstract = "Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.",
author = "Theocharis, {Achilleas D.} and Skandalis, {Spyros S.} and Thomas Neill and Multhaupt, {Hinke A. B.} and Mario Hubo and Helena Frey and Sandeep Gopal and Angelica Gomes and Nikos Afratis and Lim, {Hooi Ching} and Couchman, {John R.} and Jorge Filmus and Sanderson, {Ralph D.} and Liliana Schaefer and Iozzo, {Renato V.} and Karamanos, {Nikos K.}",
note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",
year = "2015",
month = apr,
doi = "10.1016/j.bbcan.2015.03.006",
language = "English",
volume = "1855",
pages = "276–300",
journal = "Biochimica et Biophysica Acta - Reviews on Cancer",
issn = "0304-419X",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

AU - Theocharis, Achilleas D.

AU - Skandalis, Spyros S.

AU - Neill, Thomas

AU - Multhaupt, Hinke A. B.

AU - Hubo, Mario

AU - Frey, Helena

AU - Gopal, Sandeep

AU - Gomes, Angelica

AU - Afratis, Nikos

AU - Lim, Hooi Ching

AU - Couchman, John R.

AU - Filmus, Jorge

AU - Sanderson, Ralph D.

AU - Schaefer, Liliana

AU - Iozzo, Renato V.

AU - Karamanos, Nikos K.

N1 - Copyright © 2015. Published by Elsevier B.V.

PY - 2015/4

Y1 - 2015/4

N2 - Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

AB - Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

U2 - 10.1016/j.bbcan.2015.03.006

DO - 10.1016/j.bbcan.2015.03.006

M3 - Review

C2 - 25829250

VL - 1855

SP - 276

EP - 300

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

SN - 0304-419X

IS - 2

ER -

ID: 135369861