Induction of DNA damage by oxidised amino acids and proteins

Research output: Contribution to journalJournal articleResearchpeer-review

Catherine Luxford, Roger T Dean, Michael Jonathan Davies

Exposure of amino acids, peptides and proteins to radicals in the presence of O2 generates hydroperoxides in a dose-dependent manner. These hydroperoxides are stable in the absence of exogenous catalysts (e.g. heat, light, redox-active transition metal ions), but decompose rapidly in the presence of these agents to give a variety of radicals including alkoxyl (RO*), peroxyl (ROO*) and carbon-centred (R) species. These radicals are shown to react with DNA to give DNA-protein cross-links and single strand breaks.

Original languageEnglish
JournalBiogerontology
Volume3
Issue number1-2
Pages (from-to)95-102
Number of pages8
ISSN1389-5729
Publication statusPublished - 2002

    Research areas

  • Amino Acids, Animals, Cattle, DNA Damage, Electrophoresis, Agar Gel, Hydrogen Peroxide, Oxidation-Reduction, Proteins

ID: 138278219