Increased proteoglycan synthesis by the cardiovascular system of coarctation hypertensive rats.

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D W Lipke, J R Couchman

Proteoglycan (PG) synthesis in the cardiovascular system of coarctation hypertensive rats was examined by in vivo and in vitro labeling of glycosaminoglycans with 35SO4 in rats made hypertensive for short (4 days) and longer (14 days) durations. With in vivo labeling, only tissues directly exposed to elevated pressure (left ventricle, LV and aorta above the clip, AOR increases) exhibited elevated PG synthesis after 4 days of hypertension. By 14 days, tissues both exposed to (LV and AOR increases) and protected from elevated pressure (right ventricle and kidney) exhibited elevated PG synthetic rates. Slight elevations in the proportion of galactosaminoglycans were observed with a concurrent proportional decrease in heparan sulfate PGs. Using the in vitro labeling procedure, no significant increases in PG synthesis were observed in any tissue at either 4 days or 14 days of hypertension. These data indicate that: 1) coarctation hypertension stimulates PG production that is dependent initially on increased pressure and later, on additional non-pressure related factors, 2) these other factors are responsible for enhanced PG production in tissues not directly exposed to pressure overload, 3) pressure and/or these other factors are essential for enhanced PG production in coarctation hypertension, and 4) synthesis of all GAG types appears to be affected.
Original languageEnglish
JournalJournal of Cellular Physiology
Volume147
Issue number3
Pages (from-to)479-86
Number of pages7
ISSN0021-9541
DOIs
Publication statusPublished - 1991

Bibliographical note

Keywords: Animals; Aortic Coarctation; Blood Pressure; Cardiovascular Physiology; Cardiovascular System; Glycosaminoglycans; Heart Ventricles; Hemodynamics; Hypertension; Male; Proteoglycans; Rats; Rats, Inbred Strains; Sulfates; Sulfur Radioisotopes

ID: 5166425