Hypochlorite-induced oxidation of amino acids, peptides and proteins

Research output: Contribution to journalJournal articleResearchpeer-review

C L Hawkins, D I Pattison, Michael Jonathan Davies

Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of biological targets including proteins, DNA, lipids and cholesterol. Proteins are likely to be major targets for reaction with HOCl within a cell due to their abundance and high reactivity with HOCl. This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions. The predicted targets for reaction with HOCl from kinetic modeling studies and the consequences of HOCl-induced protein oxidation are also discussed.

Original languageEnglish
JournalAmino Acids
Volume25
Issue number3-4
Pages (from-to)259-74
Number of pages16
ISSN0939-4451
DOIs
Publication statusPublished - Dec 2003

    Research areas

  • Amino Acids, Catalysis, Humans, Hydrogen Peroxide, Hypochlorous Acid, Kinetics, Oxidation-Reduction, Peptides, Peroxidase, Proteins

ID: 138274719