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Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. / Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe; Lush, Michael J; Maranian, Mel J; Bolla, Manjeet K; Wang, Qin; Shah, Mitul; Perkins, Barbara J; Czene, Kamila; Eriksson, Mikael; Darabi, Hatef; Brand, Judith S; Bojesen, Stig E; Nordestgaard, Børge G; Flyger, Henrik; Nielsen, Sune F; Rahman, Nazneen; Turnbull, Clare; Fletcher, Olivia; Peto, Julian; Gibson, Lorna; dos-Santos-Silva, Isabel; Chang-Claude, Jenny; Flesch-Janys, Dieter; Rudolph, Anja; Eilber, Ursula; Behrens, Sabine; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Khan, Sofia; Aaltonen, Kirsimari; Ahsan, Habibul; Kibriya, Muhammad G; Whittemore, Alice S; John, Esther M; Malone, Kathleen E; Gammon, Marilie D; Santella, Regina M; Ursin, Giske; Makalic, Enes; Schmidt, Daniel F; Casey, Graham; Hunter, David J; Gapstur, Susan M; Gaudet, Mia M; BOCS.
In:
Nature Genetics, Vol. 47, No. 4, 04.2015, p. 373-80 + 1 unpag.
Research output: Contribution to journal › Letter › Research › peer-review
Harvard
Michailidou, K, Beesley, J, Lindstrom, S, Canisius, S, Dennis, J, Lush, MJ, Maranian, MJ, Bolla, MK, Wang, Q, Shah, M, Perkins, BJ, Czene, K, Eriksson, M, Darabi, H, Brand, JS
, Bojesen, SE, Nordestgaard, BG, Flyger, H, Nielsen, SF, Rahman, N, Turnbull, C, Fletcher, O, Peto, J, Gibson, L, dos-Santos-Silva, I, Chang-Claude, J, Flesch-Janys, D, Rudolph, A, Eilber, U, Behrens, S, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Khan, S, Aaltonen, K, Ahsan, H, Kibriya, MG, Whittemore, AS, John, EM, Malone, KE, Gammon, MD, Santella, RM, Ursin, G, Makalic, E, Schmidt, DF, Casey, G, Hunter, DJ, Gapstur, SM, Gaudet, MM & BOCS 2015, '
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer',
Nature Genetics, vol. 47, no. 4, pp. 373-80 + 1 unpag..
https://doi.org/10.1038/ng.3242APA
Michailidou, K., Beesley, J., Lindstrom, S., Canisius, S., Dennis, J., Lush, M. J., Maranian, M. J., Bolla, M. K., Wang, Q., Shah, M., Perkins, B. J., Czene, K., Eriksson, M., Darabi, H., Brand, J. S.
, Bojesen, S. E., Nordestgaard, B. G., Flyger, H., Nielsen, S. F., ... BOCS (2015).
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature Genetics,
47(4), 373-80 + 1 unpag..
https://doi.org/10.1038/ng.3242Vancouver
Michailidou K, Beesley J, Lindstrom S, Canisius S, Dennis J, Lush MJ et al.
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Nature Genetics. 2015 Apr;47(4):373-80 + 1 unpag.
https://doi.org/10.1038/ng.3242Author
Michailidou, Kyriaki ; Beesley, Jonathan ; Lindstrom, Sara ; Canisius, Sander ; Dennis, Joe ; Lush, Michael J ; Maranian, Mel J ; Bolla, Manjeet K ; Wang, Qin ; Shah, Mitul ; Perkins, Barbara J ; Czene, Kamila ; Eriksson, Mikael ; Darabi, Hatef ; Brand, Judith S ; Bojesen, Stig E ; Nordestgaard, Børge G ; Flyger, Henrik ; Nielsen, Sune F ; Rahman, Nazneen ; Turnbull, Clare ; Fletcher, Olivia ; Peto, Julian ; Gibson, Lorna ; dos-Santos-Silva, Isabel ; Chang-Claude, Jenny ; Flesch-Janys, Dieter ; Rudolph, Anja ; Eilber, Ursula ; Behrens, Sabine ; Nevanlinna, Heli ; Muranen, Taru A ; Aittomäki, Kristiina ; Blomqvist, Carl ; Khan, Sofia ; Aaltonen, Kirsimari ; Ahsan, Habibul ; Kibriya, Muhammad G ; Whittemore, Alice S ; John, Esther M ; Malone, Kathleen E ; Gammon, Marilie D ; Santella, Regina M ; Ursin, Giske ; Makalic, Enes ; Schmidt, Daniel F ; Casey, Graham ; Hunter, David J ; Gapstur, Susan M ; Gaudet, Mia M ; BOCS. / Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. In: Nature Genetics. 2015 ; Vol. 47, No. 4. pp. 373-80 + 1 unpag.
Bibtex
@article{8a0665c9505147aa9a9de13795033ec6,
title = "Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer",
abstract = "Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.",
keywords = "Breast Neoplasms, Case-Control Studies, Cohort Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Microarray Analysis, Polymorphism, Single Nucleotide",
author = "Kyriaki Michailidou and Jonathan Beesley and Sara Lindstrom and Sander Canisius and Joe Dennis and Lush, {Michael J} and Maranian, {Mel J} and Bolla, {Manjeet K} and Qin Wang and Mitul Shah and Perkins, {Barbara J} and Kamila Czene and Mikael Eriksson and Hatef Darabi and Brand, {Judith S} and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Henrik Flyger and Nielsen, {Sune F} and Nazneen Rahman and Clare Turnbull and Olivia Fletcher and Julian Peto and Lorna Gibson and Isabel dos-Santos-Silva and Jenny Chang-Claude and Dieter Flesch-Janys and Anja Rudolph and Ursula Eilber and Sabine Behrens and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Sofia Khan and Kirsimari Aaltonen and Habibul Ahsan and Kibriya, {Muhammad G} and Whittemore, {Alice S} and John, {Esther M} and Malone, {Kathleen E} and Gammon, {Marilie D} and Santella, {Regina M} and Giske Ursin and Enes Makalic and Schmidt, {Daniel F} and Graham Casey and Hunter, {David J} and Gapstur, {Susan M} and Gaudet, {Mia M} and BOCS",
year = "2015",
month = apr,
doi = "10.1038/ng.3242",
language = "English",
volume = "47",
pages = "373--80 + 1 unpag.",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",
}
RIS
TY - JOUR
T1 - Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
AU - Michailidou, Kyriaki
AU - Beesley, Jonathan
AU - Lindstrom, Sara
AU - Canisius, Sander
AU - Dennis, Joe
AU - Lush, Michael J
AU - Maranian, Mel J
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Shah, Mitul
AU - Perkins, Barbara J
AU - Czene, Kamila
AU - Eriksson, Mikael
AU - Darabi, Hatef
AU - Brand, Judith S
AU - Bojesen, Stig E
AU - Nordestgaard, Børge G
AU - Flyger, Henrik
AU - Nielsen, Sune F
AU - Rahman, Nazneen
AU - Turnbull, Clare
AU - Fletcher, Olivia
AU - Peto, Julian
AU - Gibson, Lorna
AU - dos-Santos-Silva, Isabel
AU - Chang-Claude, Jenny
AU - Flesch-Janys, Dieter
AU - Rudolph, Anja
AU - Eilber, Ursula
AU - Behrens, Sabine
AU - Nevanlinna, Heli
AU - Muranen, Taru A
AU - Aittomäki, Kristiina
AU - Blomqvist, Carl
AU - Khan, Sofia
AU - Aaltonen, Kirsimari
AU - Ahsan, Habibul
AU - Kibriya, Muhammad G
AU - Whittemore, Alice S
AU - John, Esther M
AU - Malone, Kathleen E
AU - Gammon, Marilie D
AU - Santella, Regina M
AU - Ursin, Giske
AU - Makalic, Enes
AU - Schmidt, Daniel F
AU - Casey, Graham
AU - Hunter, David J
AU - Gapstur, Susan M
AU - Gaudet, Mia M
AU - BOCS
PY - 2015/4
Y1 - 2015/4
N2 - Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
AB - Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Cohort Studies
KW - Female
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Meta-Analysis as Topic
KW - Microarray Analysis
KW - Polymorphism, Single Nucleotide
U2 - 10.1038/ng.3242
DO - 10.1038/ng.3242
M3 - Letter
C2 - 25751625
VL - 47
SP - 373-80 + 1 unpag.
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
