From powerhouse to perpetrator—mitochondria in health and disease
Research output: Contribution to journal › Review › Research › peer-review
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From powerhouse to perpetrator—mitochondria in health and disease. / Fakouri, Nima B.; Hansen, Thomas Lau; Desler, Claus; Anugula, Sharath; Rasmussen, Lene Juel.
In: Biology, Vol. 8, No. 2, 35, 2019.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - From powerhouse to perpetrator—mitochondria in health and disease
AU - Fakouri, Nima B.
AU - Hansen, Thomas Lau
AU - Desler, Claus
AU - Anugula, Sharath
AU - Rasmussen, Lene Juel
PY - 2019
Y1 - 2019
N2 - In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.
AB - In this review we discuss the interaction between metabolic stress, mitochondrial dysfunction, and genomic instability. Unrepaired DNA damage in the nucleus resulting from excess accumulation of DNA damages and stalled replication can initiate cellular signaling responses that negatively affect metabolism and mitochondrial function. On the other hand, mitochondrial pathologies can also lead to stress in the nucleus, and cause sensitivity to DNA-damaging agents. These are examples of how hallmarks of cancer and aging are connected and influenced by each other to protect humans from disease.
KW - Cancer
KW - DNA damage
KW - Mitochondria
KW - NAD
KW - Nucleotide metabolism
U2 - 10.3390/biology8020035
DO - 10.3390/biology8020035
M3 - Review
C2 - 31083572
AN - SCOPUS:85068536365
VL - 8
JO - Biology
JF - Biology
SN - 2079-7737
IS - 2
M1 - 35
ER -
ID: 226792576