Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

Research output: Contribution to journalJournal articleResearchpeer-review

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Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. / Morland, Cecilie; Andersson, Krister A.; Haugen, Oyvind P.; Hadzic, Alena; Kleppa, Liv; Gille, Andreas; Rinholm, Johanne E.; Palibrk, Vuk; Diget, Elisabeth H.; Kennedy, Lauritz H.; Stolen, Tomas; Hennestad, Eivind; Moldestad, Olve; Cai, Yiqing; Puchades, Maja; Offermanns, Stefan; Vervaeke, Koen; Bjoras, Magnar; Wisloff, Ulrik; Storm-Mathisen, Jon; Bergersen, Linda H.

In: Nature Communications, Vol. 8, 15557, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Morland, C, Andersson, KA, Haugen, OP, Hadzic, A, Kleppa, L, Gille, A, Rinholm, JE, Palibrk, V, Diget, EH, Kennedy, LH, Stolen, T, Hennestad, E, Moldestad, O, Cai, Y, Puchades, M, Offermanns, S, Vervaeke, K, Bjoras, M, Wisloff, U, Storm-Mathisen, J & Bergersen, LH 2017, 'Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1', Nature Communications, vol. 8, 15557. https://doi.org/10.1038/ncomms15557

APA

Morland, C., Andersson, K. A., Haugen, O. P., Hadzic, A., Kleppa, L., Gille, A., ... Bergersen, L. H. (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications, 8, [15557]. https://doi.org/10.1038/ncomms15557

Vancouver

Morland C, Andersson KA, Haugen OP, Hadzic A, Kleppa L, Gille A et al. Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications. 2017;8. 15557. https://doi.org/10.1038/ncomms15557

Author

Morland, Cecilie ; Andersson, Krister A. ; Haugen, Oyvind P. ; Hadzic, Alena ; Kleppa, Liv ; Gille, Andreas ; Rinholm, Johanne E. ; Palibrk, Vuk ; Diget, Elisabeth H. ; Kennedy, Lauritz H. ; Stolen, Tomas ; Hennestad, Eivind ; Moldestad, Olve ; Cai, Yiqing ; Puchades, Maja ; Offermanns, Stefan ; Vervaeke, Koen ; Bjoras, Magnar ; Wisloff, Ulrik ; Storm-Mathisen, Jon ; Bergersen, Linda H. / Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. In: Nature Communications. 2017 ; Vol. 8.

Bibtex

@article{27403e6c195f4b4b9fd7e1af7993d2ce,
title = "Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1",
abstract = "Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.",
author = "Cecilie Morland and Andersson, {Krister A.} and Haugen, {Oyvind P.} and Alena Hadzic and Liv Kleppa and Andreas Gille and Rinholm, {Johanne E.} and Vuk Palibrk and Diget, {Elisabeth H.} and Kennedy, {Lauritz H.} and Tomas Stolen and Eivind Hennestad and Olve Moldestad and Yiqing Cai and Maja Puchades and Stefan Offermanns and Koen Vervaeke and Magnar Bjoras and Ulrik Wisloff and Jon Storm-Mathisen and Bergersen, {Linda H.}",
year = "2017",
doi = "10.1038/ncomms15557",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

AU - Morland, Cecilie

AU - Andersson, Krister A.

AU - Haugen, Oyvind P.

AU - Hadzic, Alena

AU - Kleppa, Liv

AU - Gille, Andreas

AU - Rinholm, Johanne E.

AU - Palibrk, Vuk

AU - Diget, Elisabeth H.

AU - Kennedy, Lauritz H.

AU - Stolen, Tomas

AU - Hennestad, Eivind

AU - Moldestad, Olve

AU - Cai, Yiqing

AU - Puchades, Maja

AU - Offermanns, Stefan

AU - Vervaeke, Koen

AU - Bjoras, Magnar

AU - Wisloff, Ulrik

AU - Storm-Mathisen, Jon

AU - Bergersen, Linda H.

PY - 2017

Y1 - 2017

N2 - Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.

AB - Physical exercise can improve brain function and delay neurodegeneration; however, the initial signal from muscle to brain is unknown. Here we show that the lactate receptor (HCAR1) is highly enriched in pial fibroblast-like cells that line the vessels supplying blood to the brain, and in pericyte-like cells along intracerebral microvessels. Activation of HCAR1 enhances cerebral vascular endothelial growth factor A (VEGFA) and cerebral angiogenesis. High-intensity interval exercise (5 days weekly for 7 weeks), as well as L-lactate subcutaneous injection that leads to an increase in blood lactate levels similar to exercise, increases brain VEGFA protein and capillary density in wild-type mice, but not in knockout mice lacking HCAR1. In contrast, skeletal muscle shows no vascular HCAR1 expression and no HCAR1-dependent change in vascularization induced by exercise or lactate. Thus, we demonstrate that a substance released by exercising skeletal muscle induces supportive effects in brain through an identified receptor.

U2 - 10.1038/ncomms15557

DO - 10.1038/ncomms15557

M3 - Journal article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 15557

ER -

ID: 182542082