Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

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Jesper A B Strickertsson, Claus Desler Madsen, Tomas Martin-Bertelsen, Ana Manuel Dantas Machado, Torkel Wadstrøm, Ole Winther, Lene Juel Rasmussen, Lennart Friis-Hansen

Achlorhydria caused by e.g. atrophic gastritis allows for bacterial overgrowth, which induces chronic inflammation and damage to the mucosal cells of infected individuals driving gastric malignancies and cancer. Enterococcus faecalis (E. faecalis) can colonize achlohydric stomachs and we therefore wanted to study the impact of E. faecalis infection on inflammatory response, reactive oxygen species (ROS) formation, mitochondrial respiration, and mitochondrial genetic stability in gastric mucosal cells.
Original languageEnglish
Article numbere63147
JournalPLOS ONE
Volume8
Issue number4
Pages (from-to)1-13
Number of pages13
ISSN1932-6203
DOIs
Publication statusPublished - 2013

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