Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice
Research output: Contribution to journal › Journal article › Research › peer-review
3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.
|Journal||P L o S One|
|Publication status||Published - 1 Jan 2010|
- Animals, Antineoplastic Agents, Cell Proliferation, Dideoxynucleosides, Disease Models, Animal, Drug Monitoring, Female, Fluorodeoxyglucose F18, Humans, Mice, Mice, Nude, Ovarian Neoplasms, Positron-Emission Tomography, Radiopharmaceuticals, Xenograft Model Antitumor Assays