Early detection of response to experimental chemotherapeutic Top216 with [18F]FLT and [18F]FDG PET in human ovary cancer xenografts in mice

Research output: Contribution to journalJournal articleResearchpeer-review

Mette Munk Jensen, Kamille Dumong Erichsen, Fredrik Björkling, Jacob Madsen, Peter Buhl Jensen, Liselotte Højgaard, Maxwell Sehested, Andreas Kjær

3'-Deoxy-3'-[(18)F]fluorothymidine ((18)F-FLT) is a tracer used to assess cell proliferation in vivo. The aim of the study was to use (18)F-FLT positron emission tomography (PET) to study treatment responses to a new anti-cancer compound. To do so, we studied early anti-proliferative effects of the experimental chemotherapy Top216 non-invasively by PET.
Original languageEnglish
JournalP L o S One
Volume5
Issue number9
Pages (from-to)e12965
ISSN1932-6203
DOIs
Publication statusPublished - 1 Jan 2010

    Research areas

  • Animals, Antineoplastic Agents, Cell Proliferation, Dideoxynucleosides, Disease Models, Animal, Drug Monitoring, Female, Fluorodeoxyglucose F18, Humans, Mice, Mice, Nude, Ovarian Neoplasms, Positron-Emission Tomography, Radiopharmaceuticals, Xenograft Model Antitumor Assays

ID: 34044950