Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
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- Endocrine Connections] Duodenal L cell density correlates with features of metabolic syndrome and plasma metabolites
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Background: Enteroendocrine cells are essential for the regulation of glucose metabolism, but it is unknown whether they are associated with clinical features of metabolic syndrome (MetS) and fasting plasma metabolites. Objective: We aimed to identify fasting plasma metabolites that associate with duodenal L cell, K cell and delta cell densities in subjects with MetS with ranging levels of insulin resistance. Research design and methods: In this cross-sectional study, we evaluated L, K and delta cell density in duodenal biopsies from treatment-naïve males with MetS using machinelearning methodology. Results: We identified specific clinical biomarkers and plasma metabolites associated with L cell and delta cell density. L cell density was associated with increased plasma metabolite levels including symmetrical dimethylarginine, 3-aminoisobutyric acid, kynurenine and glycine. In turn, these L cell-linked fasting plasma metabolites correlated with clinical features of MetS. Conclusions: Our results indicate a link between duodenal L cells, plasma metabolites and clinical characteristics of MetS. We conclude that duodenal L cells associate with plasma metabolites that have been implicated in human glucose metabolism homeostasis. Disentangling the causal relation between L cells and these metabolites might help to improve the (small intestinal-driven) pathophysiology behind insulin resistance in human obesity.
Original language | English |
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Journal | Endocrine Connections |
Volume | 7 |
Issue number | 5 |
Pages (from-to) | 673-680 |
ISSN | 2049-3614 |
DOIs | |
Publication status | Published - 2018 |
- Enteroendocrine cells, Incretins, Machine-learning methodology, Metabolic syndrome, Plasma metabolites
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