Development of stress ulcers assessed by gastric electrical potential difference, pH of gastric juice, and endoscopy in patients in the intensive care unit

Research output: Contribution to journalJournal articleResearchpeer-review

E Rubinstein, I Gjørup, S Schulze, T Jonsson, L Højgaard

OBJECTIVE: To assess measurement of gastric electrical potential difference, pH of gastric mucosa, and endoscopic findings in patients in intensive care units who are at risk of developing stress ulcers.

DESIGN: Open comparison with age- and sex-matched control subjects.

SETTING: Herlev Hospital, Denmark.

SUBJECTS: Sixteen consecutive patients with no history of gastrointestinal haemorrhage, coagulopathy, or ulcer disease who had been admitted to the intensive care unit, and 16 age- and sex-matched outpatients with normal endoscopic findings.

INTERVENTIONS: Upper gastrointestinal endoscopy, during which any lesions that were found were scored according to severity, the gastric potential difference, and the pH of gastric juice were measured.

OUTCOME MEASURES: Correlation between the incidence of stress ulceration found at endoscopy, gastric potential difference, and gastric pH.

RESULTS: Gastric potential difference was significantly reduced and gastric pH significantly increased in the patients in the intensive care unit (p less than 0.05 in both cases), all of whom had stress ulcers in more than one gastric segment. Nine of the patients had gastric pH readings of greater than 4.

CONCLUSION: Gastric electrical potential difference may be useful measurement for the assessment of stress ulceration in patients in intensive care units.

Original languageEnglish
Book seriesEuropean Journal of Surgery Supplement
Volume158
Issue number6-7
Pages (from-to)361-4
Number of pages4
ISSN1102-4151
Publication statusPublished - 1 Jun 1992

    Research areas

  • Adult, Aged, Case-Control Studies, Female, Gastric Acid, Gastric Acidity Determination, Gastroscopy, Humans, Hydrogen-Ion Concentration, Intensive Care Units, Male, Membrane Potentials, Middle Aged, Stomach Ulcer, Stress, Physiological, Journal Article

ID: 165884926