C-reactive protein and the risk of cancer: a mendelian randomization study

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Standard

C-reactive protein and the risk of cancer: a mendelian randomization study. / Allin, Kristine H; Nordestgaard, Børge G; Zacho, Jeppe; Tybjaerg-Hansen, Anne; Bojesen, Stig E.

In: National Cancer Institute. Journal (Print), Vol. 102, No. 3, 2010, p. 202-6.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Allin, KH, Nordestgaard, BG, Zacho, J, Tybjaerg-Hansen, A & Bojesen, SE 2010, 'C-reactive protein and the risk of cancer: a mendelian randomization study', National Cancer Institute. Journal (Print), vol. 102, no. 3, pp. 202-6. https://doi.org/10.1093/jnci/djp459

APA

Allin, K. H., Nordestgaard, B. G., Zacho, J., Tybjaerg-Hansen, A., & Bojesen, S. E. (2010). C-reactive protein and the risk of cancer: a mendelian randomization study. National Cancer Institute. Journal (Print), 102(3), 202-6. https://doi.org/10.1093/jnci/djp459

Vancouver

Allin KH, Nordestgaard BG, Zacho J, Tybjaerg-Hansen A, Bojesen SE. C-reactive protein and the risk of cancer: a mendelian randomization study. National Cancer Institute. Journal (Print). 2010;102(3):202-6. https://doi.org/10.1093/jnci/djp459

Author

Allin, Kristine H ; Nordestgaard, Børge G ; Zacho, Jeppe ; Tybjaerg-Hansen, Anne ; Bojesen, Stig E. / C-reactive protein and the risk of cancer: a mendelian randomization study. In: National Cancer Institute. Journal (Print). 2010 ; Vol. 102, No. 3. pp. 202-6.

Bibtex

@article{b99744d9a5f644688d8a45471f3cc15a,
title = "C-reactive protein and the risk of cancer: a mendelian randomization study",
abstract = "Elevated plasma levels of C-reactive protein (CRP), a marker of inflammation, are associated with an increased risk of cancer, but it is unclear whether this association is causal. We examined whether four common single-nucleotide polymorphisms (SNPs) in the CRP gene that are associated with altered plasma CRP levels are causally associated with an increased risk of cancer. The study population included participants in a prospective study (n = 10 215) and a cross-sectional study (n = 36 403) of the adult general population in Denmark, all of whom were genotyped for the CRP SNPs. The association between plasma CRP levels measured by a high-sensitivity turbidimetry assay and the risk of cancer was examined for 8224 participants in the prospective study. The hazard ratio of cancer for a doubling of the plasma CRP level was 1.09 (95{\%} confidence interval [CI] = 1.03 to 1.14). The nine most common genotype combinations of the four CRP SNPs were associated with up to a 72{\%} increase (95{\%} CI = 58{\%} to 87{\%}) in CRP levels but not with an increased risk of cancer. The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95{\%} CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer.",
author = "Allin, {Kristine H} and Nordestgaard, {B{\o}rge G} and Jeppe Zacho and Anne Tybjaerg-Hansen and Bojesen, {Stig E}",
note = "Keywords: Adult; Aged; C-Reactive Protein; Cross-Sectional Studies; Denmark; Female; Genotype; Humans; Inflammation; Male; Mendelian Randomization Analysis; Middle Aged; Neoplasms; Odds Ratio; Polymorphism, Single Nucleotide; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Tumor Markers, Biological",
year = "2010",
doi = "http://dx.doi.org/10.1093/jnci/djp459",
language = "English",
volume = "102",
pages = "202--6",
journal = "National Cancer Institute. Journal (Print)",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - C-reactive protein and the risk of cancer: a mendelian randomization study

AU - Allin, Kristine H

AU - Nordestgaard, Børge G

AU - Zacho, Jeppe

AU - Tybjaerg-Hansen, Anne

AU - Bojesen, Stig E

N1 - Keywords: Adult; Aged; C-Reactive Protein; Cross-Sectional Studies; Denmark; Female; Genotype; Humans; Inflammation; Male; Mendelian Randomization Analysis; Middle Aged; Neoplasms; Odds Ratio; Polymorphism, Single Nucleotide; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Tumor Markers, Biological

PY - 2010

Y1 - 2010

N2 - Elevated plasma levels of C-reactive protein (CRP), a marker of inflammation, are associated with an increased risk of cancer, but it is unclear whether this association is causal. We examined whether four common single-nucleotide polymorphisms (SNPs) in the CRP gene that are associated with altered plasma CRP levels are causally associated with an increased risk of cancer. The study population included participants in a prospective study (n = 10 215) and a cross-sectional study (n = 36 403) of the adult general population in Denmark, all of whom were genotyped for the CRP SNPs. The association between plasma CRP levels measured by a high-sensitivity turbidimetry assay and the risk of cancer was examined for 8224 participants in the prospective study. The hazard ratio of cancer for a doubling of the plasma CRP level was 1.09 (95% confidence interval [CI] = 1.03 to 1.14). The nine most common genotype combinations of the four CRP SNPs were associated with up to a 72% increase (95% CI = 58% to 87%) in CRP levels but not with an increased risk of cancer. The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer.

AB - Elevated plasma levels of C-reactive protein (CRP), a marker of inflammation, are associated with an increased risk of cancer, but it is unclear whether this association is causal. We examined whether four common single-nucleotide polymorphisms (SNPs) in the CRP gene that are associated with altered plasma CRP levels are causally associated with an increased risk of cancer. The study population included participants in a prospective study (n = 10 215) and a cross-sectional study (n = 36 403) of the adult general population in Denmark, all of whom were genotyped for the CRP SNPs. The association between plasma CRP levels measured by a high-sensitivity turbidimetry assay and the risk of cancer was examined for 8224 participants in the prospective study. The hazard ratio of cancer for a doubling of the plasma CRP level was 1.09 (95% confidence interval [CI] = 1.03 to 1.14). The nine most common genotype combinations of the four CRP SNPs were associated with up to a 72% increase (95% CI = 58% to 87%) in CRP levels but not with an increased risk of cancer. The estimated causal odds ratio for cancer associated with a genetically induced doubling in CRP level was 0.94 (95% CI = 0.81 to 1.08). This finding suggests that elevated CRP levels do not cause cancer.

U2 - http://dx.doi.org/10.1093/jnci/djp459

DO - http://dx.doi.org/10.1093/jnci/djp459

M3 - Journal article

VL - 102

SP - 202

EP - 206

JO - National Cancer Institute. Journal (Print)

JF - National Cancer Institute. Journal (Print)

SN - 0027-8874

IS - 3

ER -

ID: 34152019