Changes in the gastric potential difference during chemotherapy in patients with metastatic breast cancer
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Changes in the gastric potential difference during chemotherapy in patients with metastatic breast cancer. / Fabrin, B; Højgaard, L; Mouridsen, H T.
In: Acta Oncologica, Vol. 30, No. 7, 1991, p. 807-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in the gastric potential difference during chemotherapy in patients with metastatic breast cancer
AU - Fabrin, B
AU - Højgaard, L
AU - Mouridsen, H T
PY - 1991
Y1 - 1991
N2 - Nausea and vomiting are frequent side-effects of intravenous cancer chemotherapy. How these complications were related to the gastric mucosal function was investigated by measuring the gastric mucosal potential difference (PD). Eight patients with metastatic breast cancer receiving chemotherapy were investigated. The liquid junction-corrected gastric PD and pH were measured with a newly developed microelectrode. The measurements started half an hour before chemotherapy and continued for 4-5 hours. Nausea, vomiting, psychological stress and sleeping episodes were registered. The initial PD values were -34 mV +/- 8 mV (mean +/- SD). During the observation period 6 of 8 patients had one or more episodes of nausea and vomiting. All episodes were preceded by a significant decline in PD. The magnitude of the decline in PD was unrelated to the time-lag between administration of chemotherapy and the occurrence of nausea and vomiting, and there was no correlation between the time for these episodes and the time for the administration of the chemotherapy. One patient had three episodes of severe psychological stress causing a marked decline in PD. The last patient experienced no nausea, vomiting or stress and had no changes in PD. During sleeping periods PD increased significantly.
AB - Nausea and vomiting are frequent side-effects of intravenous cancer chemotherapy. How these complications were related to the gastric mucosal function was investigated by measuring the gastric mucosal potential difference (PD). Eight patients with metastatic breast cancer receiving chemotherapy were investigated. The liquid junction-corrected gastric PD and pH were measured with a newly developed microelectrode. The measurements started half an hour before chemotherapy and continued for 4-5 hours. Nausea, vomiting, psychological stress and sleeping episodes were registered. The initial PD values were -34 mV +/- 8 mV (mean +/- SD). During the observation period 6 of 8 patients had one or more episodes of nausea and vomiting. All episodes were preceded by a significant decline in PD. The magnitude of the decline in PD was unrelated to the time-lag between administration of chemotherapy and the occurrence of nausea and vomiting, and there was no correlation between the time for these episodes and the time for the administration of the chemotherapy. One patient had three episodes of severe psychological stress causing a marked decline in PD. The last patient experienced no nausea, vomiting or stress and had no changes in PD. During sleeping periods PD increased significantly.
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Breast Neoplasms
KW - Female
KW - Gastric Mucosa
KW - Humans
KW - Hydrogen-Ion Concentration
KW - Membrane Potentials
KW - Middle Aged
KW - Nausea
KW - Stress, Physiological
KW - Vomiting
KW - Journal Article
M3 - Journal article
C2 - 1764271
VL - 30
SP - 807
EP - 809
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 7
ER -
ID: 165885177