Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4

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Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. / Pakideeri Karat, Sandeep Gopal; Multhaupt, Hinke A B; Pocock, Roger; Couchman, John R.

In: Matrix Biology, Vol. 60-61, 07.2017, p. 57-69.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pakideeri Karat, SG, Multhaupt, HAB, Pocock, R & Couchman, JR 2017, 'Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4', Matrix Biology, vol. 60-61, pp. 57-69. https://doi.org/10.1016/j.matbio.2016.10.006

APA

Pakideeri Karat, S. G., Multhaupt, H. A. B., Pocock, R., & Couchman, J. R. (2017). Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. Matrix Biology, 60-61, 57-69. https://doi.org/10.1016/j.matbio.2016.10.006

Vancouver

Pakideeri Karat SG, Multhaupt HAB, Pocock R, Couchman JR. Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. Matrix Biology. 2017 Jul;60-61:57-69. https://doi.org/10.1016/j.matbio.2016.10.006

Author

Pakideeri Karat, Sandeep Gopal ; Multhaupt, Hinke A B ; Pocock, Roger ; Couchman, John R. / Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4. In: Matrix Biology. 2017 ; Vol. 60-61. pp. 57-69.

Bibtex

@article{c47142fea76746af87dd656de76a6f82,
title = "Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4",
abstract = "Cell-extracellular matrix (ECM) and cell-cell junctions that employ microfilaments are sites of tension. They are important for tissue repair, morphogenetic movements and can be emblematic of matrix contraction in fibrotic disease and the stroma of solid tumors. One cell surface receptor, syndecan-4, has been shown to regulate focal adhesions, junctions that form at the ends of microfilament bundles in response to matrix components such as fibronectin. Recently it has been shown that signaling emanating from this proteoglycan receptor includes regulation of Rho family GTPases and cytosolic calcium. While it is known that cell-ECM and cell-cell junctions may be linked, possible roles for syndecans in this process are not understood. Here we show that wild type primary fibroblasts and those lacking syndecan-4 utilize different cadherins in their adherens junctions and that tension is a major factor in this differential response. This corresponds to the reduced ability of fibroblasts lacking syndecan-4 to exert tension on the ECM and we now show that this may extend to reduced tension in cell-cell adhesion.",
author = "{Pakideeri Karat}, {Sandeep Gopal} and Multhaupt, {Hinke A B} and Roger Pocock and Couchman, {John R}",
note = "Copyright {\circledC} 2016. Published by Elsevier B.V.",
year = "2017",
month = "7",
doi = "10.1016/j.matbio.2016.10.006",
language = "English",
volume = "60-61",
pages = "57--69",
journal = "Matrix Biology",
issn = "0945-053X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4

AU - Pakideeri Karat, Sandeep Gopal

AU - Multhaupt, Hinke A B

AU - Pocock, Roger

AU - Couchman, John R

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2017/7

Y1 - 2017/7

N2 - Cell-extracellular matrix (ECM) and cell-cell junctions that employ microfilaments are sites of tension. They are important for tissue repair, morphogenetic movements and can be emblematic of matrix contraction in fibrotic disease and the stroma of solid tumors. One cell surface receptor, syndecan-4, has been shown to regulate focal adhesions, junctions that form at the ends of microfilament bundles in response to matrix components such as fibronectin. Recently it has been shown that signaling emanating from this proteoglycan receptor includes regulation of Rho family GTPases and cytosolic calcium. While it is known that cell-ECM and cell-cell junctions may be linked, possible roles for syndecans in this process are not understood. Here we show that wild type primary fibroblasts and those lacking syndecan-4 utilize different cadherins in their adherens junctions and that tension is a major factor in this differential response. This corresponds to the reduced ability of fibroblasts lacking syndecan-4 to exert tension on the ECM and we now show that this may extend to reduced tension in cell-cell adhesion.

AB - Cell-extracellular matrix (ECM) and cell-cell junctions that employ microfilaments are sites of tension. They are important for tissue repair, morphogenetic movements and can be emblematic of matrix contraction in fibrotic disease and the stroma of solid tumors. One cell surface receptor, syndecan-4, has been shown to regulate focal adhesions, junctions that form at the ends of microfilament bundles in response to matrix components such as fibronectin. Recently it has been shown that signaling emanating from this proteoglycan receptor includes regulation of Rho family GTPases and cytosolic calcium. While it is known that cell-ECM and cell-cell junctions may be linked, possible roles for syndecans in this process are not understood. Here we show that wild type primary fibroblasts and those lacking syndecan-4 utilize different cadherins in their adherens junctions and that tension is a major factor in this differential response. This corresponds to the reduced ability of fibroblasts lacking syndecan-4 to exert tension on the ECM and we now show that this may extend to reduced tension in cell-cell adhesion.

U2 - 10.1016/j.matbio.2016.10.006

DO - 10.1016/j.matbio.2016.10.006

M3 - Journal article

VL - 60-61

SP - 57

EP - 69

JO - Matrix Biology

JF - Matrix Biology

SN - 0945-053X

ER -

ID: 167584535