Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro
Research output: Contribution to journal › Journal article › Research › peer-review
Imran Rashid, David M van Reyk, Michael Jonathan Davies
Glycation of low-density lipoprotein (LDL) by reactive aldehydes, such as glycolaldehyde, can result in the cellular accumulation of cholesterol in macrophages. In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by glycolaldehyde when present at equimolar concentrations to the modifying agent. This protective effect was accompanied by inhibition of cholesterol and cholesteryl ester accumulation in human monocyte-derived macrophages incubated with the glycated LDL. Thus, carnosine and its constituent amino acids may have therapeutic potential in preventing diabetes-induced atherosclerosis.
|Number of pages||4|
|Publication status||Published - 6 Mar 2007|
- Cardiovascular Diseases, Carnosine, Diabetic Angiopathies, Foam Cells, Glycosylation, Histidine, Humans, In Vitro Techniques, Lipoproteins, LDL, Macrophages, beta-Alanine