Bacterial infection increases risk of carcinogenesis by targeting mitochondria
Research output: Contribution to journal › Review › Research › peer-review
Standard
Bacterial infection increases risk of carcinogenesis by targeting mitochondria. / Strickertsson, Jesper A.B.; Desler, Claus; Rasmussen, Lene Juel.
In: Seminars in Cancer Biology, Vol. 47, 12.2017, p. 95-100.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Bacterial infection increases risk of carcinogenesis by targeting mitochondria
AU - Strickertsson, Jesper A.B.
AU - Desler, Claus
AU - Rasmussen, Lene Juel
PY - 2017/12
Y1 - 2017/12
N2 - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.
AB - As up to a fifth of all cancers worldwide, have now been linked to microbial infections, it is essential to understand the carcinogenic nature of the bacterial/host interaction. This paper reviews the bacterial targeting of mediators of mitochondrial genomic fidelity and of mitochondrial apoptotic pathways, and compares the impact of the bacterial alteration of mitochondrial function to that of cancer. Bacterial virulence factors have been demonstrated to induce mutations of mitochondrial DNA (mtDNA) and to modulate DNA repair pathways of the mitochondria. Furthermore, virulence factors can induce or impair the intrinsic apoptotic pathway. The effect of bacterial targeting of mitochondria is analogous to behavior of mitochondria in a wide array of tumours, and this strongly suggests that mitochondrial targeting of bacteria is a risk factor for carcinogenesis.
KW - Bacterial infection
KW - Cancer
KW - DNA repair
KW - Microbiome
KW - Mitochondrial function
KW - Mitochondrial targeting
KW - Mutations
U2 - 10.1016/j.semcancer.2017.07.003
DO - 10.1016/j.semcancer.2017.07.003
M3 - Review
C2 - 28754330
AN - SCOPUS:85026484129
VL - 47
SP - 95
EP - 100
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
SN - 1044-579X
ER -
ID: 189863112