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Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. / Zhao, Zhiguo; Wen, Wanqing; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Zhang, Ben; Long, Jirong; Shu, Xiao-Ou; Schmidt, Marjanka K; Milne, Roger L; García-Closas, Montserrat; Chang-Claude, Jenny; Lindstrom, Sara; Bojesen, Stig E; Ahsan, Habibul; Aittomäki, Kristiina; Andrulis, Irene L; Anton-Culver, Hoda; Arndt, Volker; Beckmann, Matthias W; Beeghly-Fadiel, Alicia; Benitez, Javier; Blomqvist, Carl; Bogdanova, Natalia V; Børresen-Dale, Anne-Lise; Brand, Judith; Brauch, Hiltrud; Brenner, Hermann; Burwinkel, Barbara; Cai, Qiuyin; Casey, Graham; Chenevix-Trench, Georgia; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dörk, Thilo; Dumont, Martine; Fasching, Peter A; Figueroa, Jonine; Flesch-Janys, Dieter; Fletcher, Olivia; Flyger, Henrik; Fostira, Florentia; Gammon, Marilie; Giles, Graham G; Guénel, Pascal; Haiman, Christopher A; Hamann, Ute; Harrington, Patricia; Hartman, Mikael; Hooning, Maartje J; Hopper, John L; Jakubowska, Anna; Jasmine, Farzana; John, Esther M; Johnson, Nichola; Kabisch, Maria; Khan, Sofia; Kibriya, Muhammad; Knight, Julia A; Kosma, Veli-Matti; Kriege, Mieke; Kristensen, Vessela; Le Marchand, Loic; Lee, Eunjung; Li, Jingmei; Lindblom, Annika; Lophatananon, Artitaya; Luben, Robert; Lubinski, Jan; Malone, Kathleen E; Mannermaa, Arto; Manoukian, Siranoush; Margolin, Sara; Marme, Frederik; McLean, Catriona; Meijers-Heijboer, Hanne; Meindl, Alfons; Miao, Hui; Muir, Kenneth; Neuhausen, Susan L; Nevanlinna, Heli; Neven, Patrick; Olson, Janet E; Perkins, Barbara; Peterlongo, Paolo; Phillips, Kelly-Anne; Pylkäs, Katri; Rudolph, Anja; Santella, Regina; Sawyer, Elinor J; Schmutzler, Rita K; Schoemaker, Minouk; Shah, Mitul; Shrubsole, Martha; Southey, Melissa C; Swerdlow, Anthony J; Toland, Amanda E; Tomlinson, Ian; Torres, Diana; Truong, Thérèse; Ursin, Giske; Van Der Luijt, Rob B; Verhoef, Senno; Wang-Gohrke, Shan; Whittemore, Alice S; Winqvist, Robert; Pilar Zamora, M; Zhao, Hui; Dunning, Alison M; Simard, Jacques; Hall, Per; Kraft, Peter; Pharoah, Paul; Hunter, David; Easton, Douglas F; Zheng, Wei.
In:
Cancer causes & control : CCC, Vol. 27, 05.2016, p. 679-93.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Zhao, Z, Wen, W, Michailidou, K, Bolla, MK, Wang, Q, Zhang, B, Long, J, Shu, X-O, Schmidt, MK, Milne, RL, García-Closas, M, Chang-Claude, J, Lindstrom, S
, Bojesen, SE, Ahsan, H, Aittomäki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Blomqvist, C, Bogdanova, NV, Børresen-Dale, A-L, Brand, J, Brauch, H, Brenner, H, Burwinkel, B, Cai, Q, Casey, G, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dörk, T, Dumont, M, Fasching, PA, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, GG, Guénel, P, Haiman, CA, Hamann, U, Harrington, P, Hartman, M, Hooning, MJ, Hopper, JL, Jakubowska, A, Jasmine, F, John, EM, Johnson, N, Kabisch, M, Khan, S, Kibriya, M, Knight, JA, Kosma, V-M, Kriege, M, Kristensen, V, Le Marchand, L, Lee, E, Li, J, Lindblom, A, Lophatananon, A, Luben, R, Lubinski, J, Malone, KE, Mannermaa, A, Manoukian, S, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Miao, H, Muir, K, Neuhausen, SL, Nevanlinna, H, Neven, P, Olson, JE, Perkins, B, Peterlongo, P, Phillips, K-A, Pylkäs, K, Rudolph, A, Santella, R, Sawyer, EJ, Schmutzler, RK, Schoemaker, M, Shah, M, Shrubsole, M, Southey, MC, Swerdlow, AJ, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Ursin, G, Van Der Luijt, RB, Verhoef, S, Wang-Gohrke, S, Whittemore, AS, Winqvist, R, Pilar Zamora, M, Zhao, H, Dunning, AM, Simard, J, Hall, P, Kraft, P, Pharoah, P, Hunter, D, Easton, DF & Zheng, W 2016, '
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry',
Cancer causes & control : CCC, vol. 27, pp. 679-93.
https://doi.org/10.1007/s10552-016-0741-6APA
Zhao, Z., Wen, W., Michailidou, K., Bolla, M. K., Wang, Q., Zhang, B., Long, J., Shu, X-O., Schmidt, M. K., Milne, R. L., García-Closas, M., Chang-Claude, J., Lindstrom, S.
, Bojesen, S. E., Ahsan, H., Aittomäki, K., Andrulis, I. L., Anton-Culver, H., Arndt, V., ... Zheng, W. (2016).
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Cancer causes & control : CCC,
27, 679-93.
https://doi.org/10.1007/s10552-016-0741-6Vancouver
Zhao Z, Wen W, Michailidou K, Bolla MK, Wang Q, Zhang B et al.
Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry.
Cancer causes & control : CCC. 2016 May;27:679-93.
https://doi.org/10.1007/s10552-016-0741-6Author
Zhao, Zhiguo ; Wen, Wanqing ; Michailidou, Kyriaki ; Bolla, Manjeet K ; Wang, Qin ; Zhang, Ben ; Long, Jirong ; Shu, Xiao-Ou ; Schmidt, Marjanka K ; Milne, Roger L ; García-Closas, Montserrat ; Chang-Claude, Jenny ; Lindstrom, Sara ; Bojesen, Stig E ; Ahsan, Habibul ; Aittomäki, Kristiina ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arndt, Volker ; Beckmann, Matthias W ; Beeghly-Fadiel, Alicia ; Benitez, Javier ; Blomqvist, Carl ; Bogdanova, Natalia V ; Børresen-Dale, Anne-Lise ; Brand, Judith ; Brauch, Hiltrud ; Brenner, Hermann ; Burwinkel, Barbara ; Cai, Qiuyin ; Casey, Graham ; Chenevix-Trench, Georgia ; Couch, Fergus J ; Cox, Angela ; Cross, Simon S ; Czene, Kamila ; Dörk, Thilo ; Dumont, Martine ; Fasching, Peter A ; Figueroa, Jonine ; Flesch-Janys, Dieter ; Fletcher, Olivia ; Flyger, Henrik ; Fostira, Florentia ; Gammon, Marilie ; Giles, Graham G ; Guénel, Pascal ; Haiman, Christopher A ; Hamann, Ute ; Harrington, Patricia ; Hartman, Mikael ; Hooning, Maartje J ; Hopper, John L ; Jakubowska, Anna ; Jasmine, Farzana ; John, Esther M ; Johnson, Nichola ; Kabisch, Maria ; Khan, Sofia ; Kibriya, Muhammad ; Knight, Julia A ; Kosma, Veli-Matti ; Kriege, Mieke ; Kristensen, Vessela ; Le Marchand, Loic ; Lee, Eunjung ; Li, Jingmei ; Lindblom, Annika ; Lophatananon, Artitaya ; Luben, Robert ; Lubinski, Jan ; Malone, Kathleen E ; Mannermaa, Arto ; Manoukian, Siranoush ; Margolin, Sara ; Marme, Frederik ; McLean, Catriona ; Meijers-Heijboer, Hanne ; Meindl, Alfons ; Miao, Hui ; Muir, Kenneth ; Neuhausen, Susan L ; Nevanlinna, Heli ; Neven, Patrick ; Olson, Janet E ; Perkins, Barbara ; Peterlongo, Paolo ; Phillips, Kelly-Anne ; Pylkäs, Katri ; Rudolph, Anja ; Santella, Regina ; Sawyer, Elinor J ; Schmutzler, Rita K ; Schoemaker, Minouk ; Shah, Mitul ; Shrubsole, Martha ; Southey, Melissa C ; Swerdlow, Anthony J ; Toland, Amanda E ; Tomlinson, Ian ; Torres, Diana ; Truong, Thérèse ; Ursin, Giske ; Van Der Luijt, Rob B ; Verhoef, Senno ; Wang-Gohrke, Shan ; Whittemore, Alice S ; Winqvist, Robert ; Pilar Zamora, M ; Zhao, Hui ; Dunning, Alison M ; Simard, Jacques ; Hall, Per ; Kraft, Peter ; Pharoah, Paul ; Hunter, David ; Easton, Douglas F ; Zheng, Wei. / Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry. In: Cancer causes & control : CCC. 2016 ; Vol. 27. pp. 679-93.
Bibtex
@article{7b60aed46236444fb595618605e12ff9,
title = "Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry",
abstract = "PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.METHODS: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.RESULTS: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).CONCLUSIONS: We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.",
keywords = "Breast Neoplasms, Case-Control Studies, Diabetes Mellitus, Type 2, Ethnic Groups, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genetic Variation, Humans, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Risk Factors, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.",
author = "Zhiguo Zhao and Wanqing Wen and Kyriaki Michailidou and Bolla, {Manjeet K} and Qin Wang and Ben Zhang and Jirong Long and Xiao-Ou Shu and Schmidt, {Marjanka K} and Milne, {Roger L} and Montserrat Garc{\'i}a-Closas and Jenny Chang-Claude and Sara Lindstrom and Bojesen, {Stig E} and Habibul Ahsan and Kristiina Aittom{\"a}ki and Andrulis, {Irene L} and Hoda Anton-Culver and Volker Arndt and Beckmann, {Matthias W} and Alicia Beeghly-Fadiel and Javier Benitez and Carl Blomqvist and Bogdanova, {Natalia V} and Anne-Lise B{\o}rresen-Dale and Judith Brand and Hiltrud Brauch and Hermann Brenner and Barbara Burwinkel and Qiuyin Cai and Graham Casey and Georgia Chenevix-Trench and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Thilo D{\"o}rk and Martine Dumont and Fasching, {Peter A} and Jonine Figueroa and Dieter Flesch-Janys and Olivia Fletcher and Henrik Flyger and Florentia Fostira and Marilie Gammon and Giles, {Graham G} and Pascal Gu{\'e}nel and Haiman, {Christopher A} and Ute Hamann and Patricia Harrington and Mikael Hartman and Hooning, {Maartje J} and Hopper, {John L} and Anna Jakubowska and Farzana Jasmine and John, {Esther M} and Nichola Johnson and Maria Kabisch and Sofia Khan and Muhammad Kibriya and Knight, {Julia A} and Veli-Matti Kosma and Mieke Kriege and Vessela Kristensen and {Le Marchand}, Loic and Eunjung Lee and Jingmei Li and Annika Lindblom and Artitaya Lophatananon and Robert Luben and Jan Lubinski and Malone, {Kathleen E} and Arto Mannermaa and Siranoush Manoukian and Sara Margolin and Frederik Marme and Catriona McLean and Hanne Meijers-Heijboer and Alfons Meindl and Hui Miao and Kenneth Muir and Neuhausen, {Susan L} and Heli Nevanlinna and Patrick Neven and Olson, {Janet E} and Barbara Perkins and Paolo Peterlongo and Kelly-Anne Phillips and Katri Pylk{\"a}s and Anja Rudolph and Regina Santella and Sawyer, {Elinor J} and Schmutzler, {Rita K} and Minouk Schoemaker and Mitul Shah and Martha Shrubsole and Southey, {Melissa C} and Swerdlow, {Anthony J} and Toland, {Amanda E} and Ian Tomlinson and Diana Torres and Th{\'e}r{\`e}se Truong and Giske Ursin and {Van Der Luijt}, {Rob B} and Senno Verhoef and Shan Wang-Gohrke and Whittemore, {Alice S} and Robert Winqvist and {Pilar Zamora}, M and Hui Zhao and Dunning, {Alison M} and Jacques Simard and Per Hall and Peter Kraft and Paul Pharoah and David Hunter and Easton, {Douglas F} and Wei Zheng",
year = "2016",
month = may,
doi = "10.1007/s10552-016-0741-6",
language = "English",
volume = "27",
pages = "679--93",
journal = "Cancer Causes & Control",
issn = "0957-5243",
publisher = "Springer",
}
RIS
TY - JOUR
T1 - Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry
AU - Zhao, Zhiguo
AU - Wen, Wanqing
AU - Michailidou, Kyriaki
AU - Bolla, Manjeet K
AU - Wang, Qin
AU - Zhang, Ben
AU - Long, Jirong
AU - Shu, Xiao-Ou
AU - Schmidt, Marjanka K
AU - Milne, Roger L
AU - García-Closas, Montserrat
AU - Chang-Claude, Jenny
AU - Lindstrom, Sara
AU - Bojesen, Stig E
AU - Ahsan, Habibul
AU - Aittomäki, Kristiina
AU - Andrulis, Irene L
AU - Anton-Culver, Hoda
AU - Arndt, Volker
AU - Beckmann, Matthias W
AU - Beeghly-Fadiel, Alicia
AU - Benitez, Javier
AU - Blomqvist, Carl
AU - Bogdanova, Natalia V
AU - Børresen-Dale, Anne-Lise
AU - Brand, Judith
AU - Brauch, Hiltrud
AU - Brenner, Hermann
AU - Burwinkel, Barbara
AU - Cai, Qiuyin
AU - Casey, Graham
AU - Chenevix-Trench, Georgia
AU - Couch, Fergus J
AU - Cox, Angela
AU - Cross, Simon S
AU - Czene, Kamila
AU - Dörk, Thilo
AU - Dumont, Martine
AU - Fasching, Peter A
AU - Figueroa, Jonine
AU - Flesch-Janys, Dieter
AU - Fletcher, Olivia
AU - Flyger, Henrik
AU - Fostira, Florentia
AU - Gammon, Marilie
AU - Giles, Graham G
AU - Guénel, Pascal
AU - Haiman, Christopher A
AU - Hamann, Ute
AU - Harrington, Patricia
AU - Hartman, Mikael
AU - Hooning, Maartje J
AU - Hopper, John L
AU - Jakubowska, Anna
AU - Jasmine, Farzana
AU - John, Esther M
AU - Johnson, Nichola
AU - Kabisch, Maria
AU - Khan, Sofia
AU - Kibriya, Muhammad
AU - Knight, Julia A
AU - Kosma, Veli-Matti
AU - Kriege, Mieke
AU - Kristensen, Vessela
AU - Le Marchand, Loic
AU - Lee, Eunjung
AU - Li, Jingmei
AU - Lindblom, Annika
AU - Lophatananon, Artitaya
AU - Luben, Robert
AU - Lubinski, Jan
AU - Malone, Kathleen E
AU - Mannermaa, Arto
AU - Manoukian, Siranoush
AU - Margolin, Sara
AU - Marme, Frederik
AU - McLean, Catriona
AU - Meijers-Heijboer, Hanne
AU - Meindl, Alfons
AU - Miao, Hui
AU - Muir, Kenneth
AU - Neuhausen, Susan L
AU - Nevanlinna, Heli
AU - Neven, Patrick
AU - Olson, Janet E
AU - Perkins, Barbara
AU - Peterlongo, Paolo
AU - Phillips, Kelly-Anne
AU - Pylkäs, Katri
AU - Rudolph, Anja
AU - Santella, Regina
AU - Sawyer, Elinor J
AU - Schmutzler, Rita K
AU - Schoemaker, Minouk
AU - Shah, Mitul
AU - Shrubsole, Martha
AU - Southey, Melissa C
AU - Swerdlow, Anthony J
AU - Toland, Amanda E
AU - Tomlinson, Ian
AU - Torres, Diana
AU - Truong, Thérèse
AU - Ursin, Giske
AU - Van Der Luijt, Rob B
AU - Verhoef, Senno
AU - Wang-Gohrke, Shan
AU - Whittemore, Alice S
AU - Winqvist, Robert
AU - Pilar Zamora, M
AU - Zhao, Hui
AU - Dunning, Alison M
AU - Simard, Jacques
AU - Hall, Per
AU - Kraft, Peter
AU - Pharoah, Paul
AU - Hunter, David
AU - Easton, Douglas F
AU - Zheng, Wei
PY - 2016/5
Y1 - 2016/5
N2 - PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.METHODS: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.RESULTS: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).CONCLUSIONS: We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.
AB - PURPOSE: Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors.METHODS: We constructed a genetic risk score (GRS) using risk variants from 33 known independent T2D susceptibility loci and evaluated its relation to breast cancer risk using the data from two consortia, including 62,328 breast cancer patients and 83,817 controls of European ancestry. Unconditional logistic regression models were used to derive adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) to measure the association of breast cancer risk with T2D GRS or T2D-associated genetic risk variants. Meta-analyses were conducted to obtain summary ORs across all studies.RESULTS: The T2D GRS was not found to be associated with breast cancer risk, overall, by menopausal status, or for estrogen receptor positive or negative breast cancer. Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).CONCLUSIONS: We have shown that several genetic risk variants were associated with the risk of both T2D and breast cancer. However, overall genetic susceptibility to T2D may not be related to breast cancer risk.
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Diabetes Mellitus, Type 2
KW - Ethnic Groups
KW - European Continental Ancestry Group
KW - Female
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Humans
KW - Middle Aged
KW - Odds Ratio
KW - Polymorphism, Single Nucleotide
KW - Risk Factors
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
KW - Research Support, U.S. Gov't, Non-P.H.S.
U2 - 10.1007/s10552-016-0741-6
DO - 10.1007/s10552-016-0741-6
M3 - Journal article
C2 - 27053251
VL - 27
SP - 679
EP - 693
JO - Cancer Causes & Control
JF - Cancer Causes & Control
SN - 0957-5243
ER -
