Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

Research output: Contribution to journalJournal articleResearchpeer-review

Chang Cheng, Nina F Jeppesen Edin, Knut H Lauritzen, Ida Aspmodal, Stine Christoffersen, Liu Jian, Lene Juel Rasmussen, Erik O Pettersen, Gao Xiaoqun, Linda H Bergersen

Tumour cells are characterized by aerobic glycolysis, which provides biomass for tumour proliferation and leads to extracellular acidification through efflux of lactate via monocarboxylate transporters (MCTs). Deficient and spasm-prone tumour vasculature causes variable hypoxia, which favours tumour cell survival and metastases. Brain metastases frequently occur in patients with advanced breast cancer.Effective treatment strategies are therefore needed against brain metastasis from breast carcinoma.
Original languageEnglish
JournalCellular oncology (Dordrecht)
Volume35
Issue number3
Pages (from-to)217-27
Number of pages11
DOIs
Publication statusPublished - Jun 2012

ID: 40802359