AHRR hypomethylation, lung function, lung function decline and respiratory symptoms

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AHRR hypomethylation, lung function, lung function decline and respiratory symptoms. / Kodal, Jakob B; Kobylecki, Camilla J; Vedel-Krogh, Signe; Nordestgaard, Børge G; Bojesen, Stig E.

In: The European Respiratory Journal, Vol. 51, No. 3, 1701512, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kodal, JB, Kobylecki, CJ, Vedel-Krogh, S, Nordestgaard, BG & Bojesen, SE 2018, 'AHRR hypomethylation, lung function, lung function decline and respiratory symptoms', The European Respiratory Journal, vol. 51, no. 3, 1701512. https://doi.org/10.1183/13993003.01512-2017

APA

Kodal, J. B., Kobylecki, C. J., Vedel-Krogh, S., Nordestgaard, B. G., & Bojesen, S. E. (2018). AHRR hypomethylation, lung function, lung function decline and respiratory symptoms. The European Respiratory Journal, 51(3), [1701512]. https://doi.org/10.1183/13993003.01512-2017

Vancouver

Kodal JB, Kobylecki CJ, Vedel-Krogh S, Nordestgaard BG, Bojesen SE. AHRR hypomethylation, lung function, lung function decline and respiratory symptoms. The European Respiratory Journal. 2018;51(3). 1701512. https://doi.org/10.1183/13993003.01512-2017

Author

Kodal, Jakob B ; Kobylecki, Camilla J ; Vedel-Krogh, Signe ; Nordestgaard, Børge G ; Bojesen, Stig E. / AHRR hypomethylation, lung function, lung function decline and respiratory symptoms. In: The European Respiratory Journal. 2018 ; Vol. 51, No. 3.

Bibtex

@article{c95c91b68a9c44ed8b4b7fb95e2c5344,
title = "AHRR hypomethylation, lung function, lung function decline and respiratory symptoms",
abstract = "Epigenome-wide association studies have shown a consistent association between smoking exposure and hypomethylation in the aryl hydrocarbon receptor repressor (AHRR) gene (cg05575921). We tested the hypothesis that AHRR hypomethylation is associated with low lung function, steeper lung function decline, and respiratory symptoms in the general population.AHRR methylation extent was measured in 9113 individuals from the 1991-1994 examination of the Copenhagen City Heart Study, using bisulfite-treated leukocyte DNA. Spirometry at the time of blood sampling was available for all individuals. Lung function was measured again for 4532 of these individuals in 2001-2003.Cross-sectionally, a 10{\%} lower methylation extent was associated with a 0.2 z-score (95{\%} CI 0.1-0.2) lower forced expiratory volume in 1 s (FEV1) after multivariable adjustment including smoking. Hypomethylation was also associated with a lower z-score for both forced vital capacity (FVC) and FEV1/FVC. In prospective analyses, individuals in the lowest versus highest tertile of methylation extent had a steeper decline in FEV1/height3 (p for examination×methylation interaction=0.003) and FVC/height3 (p=0.01), but not FEV1/FVC (p=0.08). Multivariable-adjusted odds ratios per 10{\%} lower methylation extent were 1.31 (95{\%} CI 1.18-1.45) for chronic bronchitis and 1.21 (95{\%} CI 1.13-1.30) for any respiratory symptoms.AHRR hypomethylation was associated with low lung function, steeper lung function decline, and respiratory symptoms.",
author = "Kodal, {Jakob B} and Kobylecki, {Camilla J} and Signe Vedel-Krogh and Nordestgaard, {B{\o}rge G} and Bojesen, {Stig E}",
note = "Copyright {\circledC}ERS 2018.",
year = "2018",
doi = "10.1183/13993003.01512-2017",
language = "English",
volume = "51",
journal = "The European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "3",

}

RIS

TY - JOUR

T1 - AHRR hypomethylation, lung function, lung function decline and respiratory symptoms

AU - Kodal, Jakob B

AU - Kobylecki, Camilla J

AU - Vedel-Krogh, Signe

AU - Nordestgaard, Børge G

AU - Bojesen, Stig E

N1 - Copyright ©ERS 2018.

PY - 2018

Y1 - 2018

N2 - Epigenome-wide association studies have shown a consistent association between smoking exposure and hypomethylation in the aryl hydrocarbon receptor repressor (AHRR) gene (cg05575921). We tested the hypothesis that AHRR hypomethylation is associated with low lung function, steeper lung function decline, and respiratory symptoms in the general population.AHRR methylation extent was measured in 9113 individuals from the 1991-1994 examination of the Copenhagen City Heart Study, using bisulfite-treated leukocyte DNA. Spirometry at the time of blood sampling was available for all individuals. Lung function was measured again for 4532 of these individuals in 2001-2003.Cross-sectionally, a 10% lower methylation extent was associated with a 0.2 z-score (95% CI 0.1-0.2) lower forced expiratory volume in 1 s (FEV1) after multivariable adjustment including smoking. Hypomethylation was also associated with a lower z-score for both forced vital capacity (FVC) and FEV1/FVC. In prospective analyses, individuals in the lowest versus highest tertile of methylation extent had a steeper decline in FEV1/height3 (p for examination×methylation interaction=0.003) and FVC/height3 (p=0.01), but not FEV1/FVC (p=0.08). Multivariable-adjusted odds ratios per 10% lower methylation extent were 1.31 (95% CI 1.18-1.45) for chronic bronchitis and 1.21 (95% CI 1.13-1.30) for any respiratory symptoms.AHRR hypomethylation was associated with low lung function, steeper lung function decline, and respiratory symptoms.

AB - Epigenome-wide association studies have shown a consistent association between smoking exposure and hypomethylation in the aryl hydrocarbon receptor repressor (AHRR) gene (cg05575921). We tested the hypothesis that AHRR hypomethylation is associated with low lung function, steeper lung function decline, and respiratory symptoms in the general population.AHRR methylation extent was measured in 9113 individuals from the 1991-1994 examination of the Copenhagen City Heart Study, using bisulfite-treated leukocyte DNA. Spirometry at the time of blood sampling was available for all individuals. Lung function was measured again for 4532 of these individuals in 2001-2003.Cross-sectionally, a 10% lower methylation extent was associated with a 0.2 z-score (95% CI 0.1-0.2) lower forced expiratory volume in 1 s (FEV1) after multivariable adjustment including smoking. Hypomethylation was also associated with a lower z-score for both forced vital capacity (FVC) and FEV1/FVC. In prospective analyses, individuals in the lowest versus highest tertile of methylation extent had a steeper decline in FEV1/height3 (p for examination×methylation interaction=0.003) and FVC/height3 (p=0.01), but not FEV1/FVC (p=0.08). Multivariable-adjusted odds ratios per 10% lower methylation extent were 1.31 (95% CI 1.18-1.45) for chronic bronchitis and 1.21 (95% CI 1.13-1.30) for any respiratory symptoms.AHRR hypomethylation was associated with low lung function, steeper lung function decline, and respiratory symptoms.

U2 - 10.1183/13993003.01512-2017

DO - 10.1183/13993003.01512-2017

M3 - Journal article

VL - 51

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 3

M1 - 1701512

ER -

ID: 218515526