Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. Published

    Mitochondrial helicases and mitochondrial genome maintenance. / de Souza-Pinto, Nadja C; Aamann, Maria Diget; Kulikowicz, Tomasz; Stevnsner, Tinna V.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 2010, p. 503-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. / de Souza-Pinto, Nadja C; Maynard, Scott; Hashiguchi, Kazunari; Hu, Jingping; Muftuoglu, Meltem; Bohr, Vilhelm A.

    In: Molecular and Cellular Biology, Vol. 29, No. 16, 08.2009, p. 4441-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. / Zheng, Jin; Croteau, Deborah L; Bohr, Vilhelm; Akbari, Mansour.

    In: Nucleic Acids Research, 31.01.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. / Yang, Jenq-Lin; Tadokoro, Takashi; Keijzers, Guido; Mattson, Mark P; Bohr, Vilhelm.

    In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28191-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Sarcopenia, Aging and Prospective Interventional Strategies. / Waltz, Tyler B; Fivenson, Elayne M; Morevati, Marya; Li, Chuanhao; Becker, Kevin G; Bohr, Vilhelm A; Fang, Evandro F.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5588-5596.

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Modulation of DNA base excision repair during neuronal differentiation. / Sykora, Peter; Yang, Jenq-Lin; Ferrarelli, Leslie K; Tian, Jingyan; Tadokoro, Takashi; Kulkarni, Avanti; Weissman, Lior; Keijzers, Guido; Wilson, David M; Mattson, Mark P; Bohr, Vilhelm A.

    In: Neurobiology of Aging, Vol. 34, No. 7, 07.2013, p. 1717-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Aprataxin localizes to mitochondria and preserves mitochondrial function. / Sykora, Peter; Croteau, Deborah L; Bohr, Vilhelm A; Wilson, David M.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 108, No. 18, 03.05.2011, p. 7437-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    DNA polymerase beta participates in mitochondrial DNA repair. / Sykora, P; Kanno, S; Akbari, M; Kulikowicz, T; Baptiste, B A; Leandro, G S; Lu, H; Tian, J; May, A; Becker, K A; Croteau, D L; Wilson, D M; Sobol, R W; Yasui, A; Bohr, V A.

    In: Molecular and Cellular Biology, Vol. 37, No. 16, e00237-17, 08.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Human RecQL4 helicase plays critical roles in prostate carcinogenesis. / Su, Yanrong; Meador, Jarah A; Calaf, Gloria M; Proietti De-Santis, Luca; Zhao, Yongliang; Bohr, Vilhelm A; Balajee, Adayabalam S.

    In: Cancer Research, Vol. 70, No. 22, 15.11.2010, p. 9207-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Human RECQL5beta stimulates flap endonuclease 1. / Speina, Elzbieta; Dawut, Lale; Hedayati, Mohammad; Wang, Zhengming; May, Alfred; Schwendener, Sybille; Janscak, Pavel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Nucleic Acids Symposium Series, Vol. 38, No. 9, 01.05.2010, p. 2904-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. / Soerensen, Mette; Dato, Serena; Christensen, Kaare; McGue, Matt; Stevnsner, Tinna V.; Bohr, Vilhelm A; Christiansen, Lene.

    In: Aging Cell, Vol. 9, No. 6, 01.12.2010, p. 1010-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The involvement of human RECQL4 in DNA double-strand break repair. / Singh, Dharmendra Kumar; Karmakar, Parimal; Aamann, Maria Diget; Schurman, Shepherd H; May, Alfred; Croteau, Deborah L; Burks, Lynnette; Plon, Sharon E; Bohr, Vilhelm A.

    In: Aging Cell, Vol. 9, No. 3, 01.06.2010, p. 358-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX. / Shamanna, Raghavendra A; Singh, Dharmendra Kumar; Lu, Huiming; Mirey, Gladys; Keijzers, Guido; Salles, Bernard; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Carcinogenesis, Vol. 35, No. 11, 11.2014, p. 2415-2424.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Protecting the mitochondrial powerhouse. / Scheibye-Knudsen, Morten; Fang, Evandro F.; Croteau, Deborah L.; Wilson, David M.; Bohr, Vilhelm A.

    In: Trends in Cell Biology, Vol. 25, No. 3, 01.03.2015, p. 158-170.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. / Scheibye-Knudsen, Morten; Ramamoorthy, Mahesh; Sykora, Peter; Maynard, Scott; Lin, Ping-Chang; Minor, Robin K; Wilson, David M; Cooper, Marcus; Spencer, Richard; de Cabo, Rafael; Croteau, Deborah L; Bohr, Vilhelm A.

    In: The Journal of Experimental Medicine, Vol. 209, No. 4, 04.2012, p. 855-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. / Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei; Iyama, Teruaki; Bharti, Sanjay Kumar; Marosi, Krisztina; Froetscher, Lynn; Kassahun, Henok; Eckley, David Mark; Maul, Robert W.; Bastian, Paul; De, Supriyo; Ghosh, Soumita; Nilsen, Hilde; Goldberg, Ilya G.; Mattson, Mark P.; Wilson, David M., III; Brosh, Robert M., Jr.; Gorospe, Myriam; Bohr, Vilhelm A.

    In: National Academy of Sciences. Proceedings, Vol. 113, No. 44, 01.11.2016, p. 12502-12507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders. / Scheibye-Knudsen, Morten; Fang, Evandro Fei; Croteau, Deborah L.; Bohr, Vilhelm A.

    In: Autophagy, Vol. 10, No. 8, 2014, p. 1468-1469.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome. / Scheibye-Knudsen, Morten; Mitchell, Sarah J.; Fang, Evandro F.; Iyama, Teruaki; Ward, Theresa; Wang, James; Dunn, Christopher A.; Singh, Nagendra; Veith, Sebastian; Hasan-Olive, Md Mahdi; Mangerich, Aswin; Wilson, Mark A.; Mattson, Mark P.; Bergersen, Linda H.; Cogger, Victoria C.; Warren, Alessandra; Le Couteur, David G.; Moaddel, Ruin; Wilson, David M.; Croteau, Deborah L.; De Cabo, Rafael; Bohr, Vilhelm A.

    In: Cell Metabolism, Vol. 20, No. 5, 04.11.2014, p. 840-855.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Roles of Werner syndrome protein in protection of genome integrity. / Rossi, Marie L; Ghosh, Avik K; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 3, 02.03.2010, p. 331-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. / Rossi, Marie L; Ghosh, Avik K; Kulikowicz, Tomasz; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 7, 01.07.2010, p. 796-804.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. / Rhee, David B; Ghosh, Avik; Lu, Jian; Bohr, Vilhelm A; Liu, Yie.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 34-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Aging, longevity and health. / Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, 23.07.2011, p. 522-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Mitochondria and aging. / Prolla, Tomas A; Bohr, Vilhelm A; de Souza-Pinto, Nadja C.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 07.2010, p. 449-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. / Popuri, Venkateswarlu; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 6, 04.06.2010, p. 636-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover. / Nygaard, Rie Harboe; Maynard, Scott; Schjerling, Peter; Kjær, Michael; Qvortrup, Klaus; Bohr, Vilhelm A; Rasmussen, Lene J; Jemec, Gregor B E; Heidenheim, Michael.

    In: Case Reports in Dermatology, Vol. 8, No. 1, 14.06.2016, p. 42-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells. / Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanád Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Jadhav, Ajit; Gileadi, Opher; Maloney, David J; Simeonov, Anton; Hickson, Ian D.

    In: Chemistry & Biology, Vol. 20, No. 1, 24.01.2013, p. 55-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. / Muftuoglu, Meltem; de Souza-Pinto, Nadja C; Dogan, Arin; Aamann, Maria; Stevnsner, Tinna; Rybanska, Ivana; Kirkali, Güldal; Dizdaroglu, Miral; Bohr, Vilhelm A.

    In: Journal of Biological Chemistry, Vol. 284, No. 14, 04.2009, p. 9270-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Acetylation regulates WRN catalytic activities and affects base excision DNA repair. / Muftuoglu, Meltem; Kusumoto, Rika; Speina, Elzbieta; Beck, Gad; Cheng, Wen-Hsing; Bohr, Vilhelm A.

    In: P L o S One, Vol. 3, No. 4, 01.2008, p. e1918.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. / McCord, Ronald A; Michishita, Eriko; Hong, Tao; Berber, Elisabeth; Boxer, Lisa D; Kusumoto, Rika; Guan, Shenheng; Shi, Xiaobing; Gozani, Or; Burlingame, Alma L; Bohr, Vilhelm A; Chua, Katrin F.

    In: Aging, Vol. 1, No. 1, 01.01.2009, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Base excision repair of oxidative DNA damage and association with cancer and aging. / Maynard, Scott; Schurman, Shepherd H; Harboe, Charlotte; de Souza-Pinto, Nadja C; Bohr, Vilhelm A.

    In: Carcinogenesis, Vol. 30, No. 1, 01.01.2009, p. 2-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. / Maynard, Scott; Hejl, Anne-Mette; Dinh, Tran Thuan Son; Keijzers, Guido; Hansen, Åse M; Madsen, Claus Desler; Moreno-Villanueva, Maria; Bürkle, Alexander; Rasmussen, Lene J; Waldemar, Gunhild; Bohr, Vilhelm A.

    In: Aging, Vol. 7, No. 10, 10.2015, p. 793-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Mitochondrial base excision repair assays. / Maynard, Scott; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten; Bohr, Vilhelm A.

    In: Methods, Vol. 51, No. 4, 01.08.2010, p. 416-25.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. / Maynard, Scott; Swistowska, Anna Maria; Lee, Jae Wan; Liu, Ying; Liu, Su-Ting; Da Cruz, Alexandre Bettencourt; Rao, Mahendra; de Souza-Pinto, Nadja C; Zeng, Xianmin; Bohr, Vilhelm A.

    In: Stem Cells, Vol. 26, No. 9, 01.09.2008, p. 2266-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration. / Maynard, Scott; Fang, Evandro Fei; Scheibye-Knudsen, Morten; Croteau, Deborah L.; Bohr, Vilhelm A.

    In: Cold Spring Harbor Perspectives in Medicine, Vol. 5, No. 10, a025130, 10.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. / Maynard, S; Keijzers, G; Hansen, Åse Marie; Osler, M; Molbo, D; Bendix, L; Møller, P; Loft, S; Moreno-Villanueva, M; Bürkle, A; Hvitby, Christina Poulsen; Schurman, S H; Stevnsner, Tinna V.; Rasmussen, L J; Avlund, K; Bohr, V A.

    In: Acta Physiologica (Print), Vol. 213, No. 1, 01.2015, p. 156-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms. / Massip, L; Garand, C; Labbé, A; Perreault, E; Turaga, R V N; Bohr, V A; Lebel, M.

    In: Oncogene, Vol. 29, No. 10, 11.03.2010, p. 1486-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions. / Liu, Dong; Croteau, Deborah L; Souza-Pinto, Nadja; Pitta, Michael; Tian, Jingyan; Wu, Christopher; Jiang, Haiyang; Mustafa, Khadija; Keijzers, Guido; Bohr, Vilhelm; Mattson, Mark P.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 2, 02.2011, p. 680-692.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis. / Li, Xiaolin; Fang, Evandro Fei; Scheibye-Knudsen, Morten; Cui, Honghua; Qiu, Lu; Li, Jian; He, Yuping; Huang, Jing; Bohr, Vilhelm A.; Ng, Tzi Bun; Guo, Hongwei.

    In: Scientific Reports, Vol. 4, 6434, 2014.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Earl R. Stadtman. / Levine, Rodney L; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 1, 01.01.2010, p. 1.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Metabolism, genomics, and DNA repair in the mouse aging liver. / Lebel, Michel; de Souza-Pinto, Nadja C; Bohr, Vilhelm A.

    In: Current Gerontology and Geriatrics Research, Vol. 2011, 01.01.2011, p. 859415.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. / Lauritzen, Knut H.; Hasan-Olive, Md Mahdi; Regnell, Christine E.; Kleppa, Liv; Scheibye-Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A.; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurobiology of Aging, Vol. 48, 12.2016, p. 34-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. / Lachapelle, Sophie; Gagné, Jean-Philippe; Garand, Chantal; Desbiens, Myriam; Coulombe, Yan; Bohr, Vilhelm A; Hendzel, Michael J; Masson, Jean-Yves; Poirier, Guy G; Lebel, Michel.

    In: Journal of Proteome Research, Vol. 10, No. 3, 04.03.2011, p. 1216-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. / Kusumoto-Matsuo, Rika; Opresko, Patricia L; Ramsden, Dale; Tahara, Hidetoshi; Bohr, Vilhelm A.

    In: Aging, Vol. 2, No. 5, 01.05.2010, p. 274-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Mitophagy and Alzheimer's Disease : Cellular and Molecular Mechanisms. / Kerr, Jesse S.; Adriaanse, Bryan A.; Greig, Nigel H.; Mattson, Mark P.; Cader, M. Zameel; Bohr, Vilhelm A.; Fang, Evandro F.

    In: Trends in Neurosciences, Vol. 40, No. 3, 2017, p. 151-166.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

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