Vilhelm Bohr

Vilhelm Bohr

Affiliate professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 3: Individualized health


  1. 2019
  2. E-pub ahead of print

    Lamin A/C promotes DNA base excision repair. / Maynard, Scott; Keijzers, Guido; Akbari, Mansour; Ezra, Michael Ben; Hall, Arnaldur; Morevati, Marya; Scheibye-Knudsen, Morten; Gonzalo, Susana; Bartek, Jiri; Bohr, Vilhelm A.

    In: Nucleic Acids Research, 24.10.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Mitochondria in the signaling pathways that control longevity and health span. / Akbari, Mansour; Kirkwood, Thomas B L; Bohr, Vilhelm A.

    In: Ageing Research Reviews, 12.08.2019, p. 100940.

    Research output: Contribution to journalReviewResearchpeer-review

  4. E-pub ahead of print

    Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. / Fang, Evandro F; Hou, Yujun; Palikaras, Konstantinos; Adriaanse, Bryan A; Kerr, Jesse S; Yang, Beimeng; Lautrup, Sofie; Hasan-Olive, Md Mahdi; Caponio, Domenica; Dan, Xiuli; Rocktäschel, Paula; Croteau, Deborah L; Akbari, Mansour; Greig, Nigel H; Fladby, Tormod; Nilsen, Hilde; Cader, M Zameel; Mattson, Mark P; Tavernarakis, Nektarios; Bohr, Vilhelm A.

    In: Nature Neuroscience, 11.02.2019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. / Zheng, Jin; Croteau, Deborah L; Bohr, Vilhelm; Akbari, Mansour.

    In: Nucleic Acids Research, Vol. 47, No. 8, 2019, p. 4086–4110.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Emerging Antitumor Activities of the Bitter Melon (Momordica charantia). / Fang, Evandro Fei; Froetscher, Lynn; Scheibye-Knudsen, Morten; Bohr, Vilhelm A; Wong, Jack Ho; Ng, Tzi Bun.

    In: Current Protein and Peptide Science, Vol. 20, No. 3, 2019, p. 296-301.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2018
  8. Published

    NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. / Hou, Yujun; Lautrup, Sofie; Cordonnier, Stephanie; Wang, Yue; Croteau, Deborah L.; Zavala, Eduardo; Zhang, Yongqing; Moritoh, Kanako; O’Connell, Jennifer F.; Baptiste, Beverly A.; Stevnsner, Tinna V.; Mattson, Mark P.; Bohr, Vilhelm A.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, No. 8, 2018, p. E1876-E1885.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Sarcopenia, Aging and Prospective Interventional Strategies. / Waltz, Tyler B; Fivenson, Elayne M; Morevati, Marya; Li, Chuanhao; Becker, Kevin G; Bohr, Vilhelm A; Fang, Evandro F.

    In: Current Medicinal Chemistry, Vol. 25, No. 40, 2018, p. 5588-5596.

    Research output: Contribution to journalReviewResearchpeer-review

  10. 2017
  11. Published

    DNA polymerase beta participates in mitochondrial DNA repair. / Sykora, P; Kanno, S; Akbari, M; Kulikowicz, T; Baptiste, B A; Leandro, G S; Lu, H; Tian, J; May, A; Becker, K A; Croteau, D L; Wilson, D M; Sobol, R W; Yasui, A; Bohr, V A.

    In: Molecular and Cellular Biology, Vol. 37, No. 16, e00237-17, 08.2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Cockayne syndrome : Clinical features, model systems and pathways. / Karikkineth, Ajoy C; Scheibye-Knudsen, Morten; Fivenson, Elayne; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Ageing Research Reviews, Vol. 33, 01.2017, p. 3-17.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Genome instability in Alzheimer disease. / Hou, Yujun; Song, Hyundong; Croteau, Deborah L; Akbari, Mansour; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 161, No. part A, 01.2017, p. 83-94.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    In Vitro and In Vivo Detection of Mitophagy in Human Cells, C. Elegans, and Mice. / Fang, Evandro F.; Palikaras, Konstantinos; Sun, Nuo; Fivenson, Elayne M.; Spangler, Ryan D.; Kerr, Jesse S.; Cordonnier, Stephanie A.; Hou, Yujun; Dombi, Eszter; Kassahun, Henok; Tavernarakis, Nektarios; Poulton, Joanna; Nilsen, Hilde; Bohr, Vilhelm A.

    In: Journal of Visualized Experiments, No. 129, e56301, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Mitophagy and Alzheimer's Disease : Cellular and Molecular Mechanisms. / Kerr, Jesse S.; Adriaanse, Bryan A.; Greig, Nigel H.; Mattson, Mark P.; Cader, M. Zameel; Bohr, Vilhelm A.; Fang, Evandro F.

    In: Trends in Neurosciences, Vol. 40, No. 3, 2017, p. 151-166.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Mitophagy in neurodegeneration and aging. / Fivenson, Elayne M; Lautrup, Sofie; Sun, Nuo; Scheibye-Knudsen, Morten; Stevnsner, Tinna; Nilsen, Hilde; Bohr, Vilhelm A; Fang, Evandro Fei.

    In: Neurochemistry International, Vol. 109, 2017, p. 202-209.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    NAD+ in Aging : Molecular Mechanisms and Translational Implications. / Fang, Evandro F.; Lautrup, Sofie; Hou, Yujun; Demarest, Tyler G.; Croteau, Deborah L.; Mattson, Mark P.; Bohr, Vilhelm A.

    In: Trends in Molecular Medicine, Vol. 23, No. 10, 2017, p. 899-916.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis. / Fakouri, Nima Borhan; Durhuus, Jon Ambaek; Regnell, Christine Elisabeth; Angleys, Maria; Desler, Claus; Hasan-Olive, Mahdi; Martin-Pardillos, Ana; Tsaalbi-Shtylik, Anastasia; Thomsen, Kirsten; Lauritzen, Martin; Bohr, Vilhelm A.; de Wind, Niels; Bergersen, Linda Hildegard; Rasmussen, Lene Juel.

    In: Scientific Reports, Vol. 7, 12480, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway. / Fang, Evandro Fei; Waltz, Tyler B; Kassahun, Henok; Lu, Qiping; Kerr, Jesse S; Morevati, Marya; Fivenson, Elayne M; Wollman, Bradley N; Marosi, Krisztina; Wilson, Mark A; Iser, Wendy B; Eckley, David Mark; Zhang, Yongqing; Lehrmann, Elin; Goldberg, Ilya G.; Scheibye-Knudsen, Morten; Mattson, Mark P.; Nilsen, Hilde; Bohr, Vilhelm A; Becker, Kevin G.

    In: Scientific Reports, Vol. 7, 46208, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2016
  21. Published

    A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. / Lauritzen, Knut H.; Hasan-Olive, Md Mahdi; Regnell, Christine E.; Kleppa, Liv; Scheibye-Knudsen, Morten; Gjedde, Albert; Klungland, Arne; Bohr, Vilhelm A.; Storm-Mathisen, Jon; Bergersen, Linda H.

    In: Neurobiology of Aging, Vol. 48, 12.2016, p. 34-47.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA. / Scheibye-Knudsen, Morten; Tseng, Anne; Jensen, Martin Borch; Scheibye-Alsing, Karsten; Fang, Evandro Fei; Iyama, Teruaki; Bharti, Sanjay Kumar; Marosi, Krisztina; Froetscher, Lynn; Kassahun, Henok; Eckley, David Mark; Maul, Robert W.; Bastian, Paul; De, Supriyo; Ghosh, Soumita; Nilsen, Hilde; Goldberg, Ilya G.; Mattson, Mark P.; Wilson, David M., III; Brosh, Robert M., Jr.; Gorospe, Myriam; Bohr, Vilhelm A.

    In: National Academy of Sciences. Proceedings, Vol. 113, No. 44, 01.11.2016, p. 12502-12507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. / Fang, Evandro Fei; Kassahun, Henok; Croteau, Deborah L; Scheibye-Knudsen, Morten; Marosi, Krisztina; Lu, Huiming; Shamanna, Raghavendra A; Kalyanasundaram, Sumana; Bollineni, Ravi Chand; Wilson, Mark A; Iser, Wendy B; Wollman, Bradley N; Morevati, Marya; Li, Jun; Kerr, Jesse S; Lu, Qiping; Waltz, Tyler B; Tian, Jane; Sinclair, David A; Mattson, Mark P; Nilsen, Hilde; Bohr, Vilhelm A.

    In: Cell Metabolism, Vol. 24, No. 4, 11.10.2016, p. 566-581.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks. / Lu, Huiming; Shamanna, Raghavendra A; Keijzers, Guido; Anand, Roopesh; Rasmussen, Lene Juel; Cejka, Petr; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell Reports, Vol. 16, No. 1, 28.06.2016, p. 161-173.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover. / Nygaard, Rie Harboe; Maynard, Scott; Schjerling, Peter; Kjær, Michael; Qvortrup, Klaus; Bohr, Vilhelm A; Rasmussen, Lene J; Jemec, Gregor B E; Heidenheim, Michael.

    In: Case Reports in Dermatology, Vol. 8, No. 1, 14.06.2016, p. 42-51.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Nuclear DNA damage signalling to mitochondria in ageing. / Fang, Evandro Fei; Scheibye-Knudsen, Morten; Chua, Katrin F; Mattson, Mark P; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Nature Reviews. Molecular Cell Biology, Vol. 17, No. 5, 05.2016, p. 308-321.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2015
  28. A research agenda for aging in China in the 21st century. / Fang, Evandro Fei; Scheibye-Knudsen, Morten; Jahn, Heiko J; Li, Juan; Ling, Li; Guo, Hongwei; Zhu, Xinqiang; Preedy, Victor; Lu, Huiming; Bohr, Vilhelm A; Chan, Wai Yee; Liu, Yuanli; Ng, Tzi Bun.

    In: Ageing Research Reviews, Vol. 24, No. Pt B, 11.2015, p. 197-205.

    Research output: Contribution to journalReviewResearchpeer-review

  29. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline. / Madsen, Claus Desler; Frederiksen, Jane H; Olsen, Maria Nathalie Angleys; Maynard, Scott; Keijzers, Guido; Fagerlund, Birgitte; Mortensen, Erik Lykke; Osler, Merete; Lauritzen, Martin; Bohr, Vilhelm A; Rasmussen, Lene Juel.

    In: Mitochondrion, Vol. 25, 11.2015, p. 34-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    DNA Damage, DNA Repair, Aging, and Neurodegeneration. / Maynard, Scott; Fang, Evandro Fei; Scheibye-Knudsen, Morten; Croteau, Deborah L.; Bohr, Vilhelm A.

    In: Cold Spring Harbor Perspectives in Medicine, Vol. 5, No. 10, a025130, 10.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. / Maynard, Scott; Hejl, Anne-Mette; Dinh, Tran Thuan Son; Keijzers, Guido; Hansen, Åse M; Madsen, Claus Desler; Moreno-Villanueva, Maria; Bürkle, Alexander; Rasmussen, Lene J; Waldemar, Gunhild; Bohr, Vilhelm A.

    In: Aging, Vol. 7, No. 10, 10.2015, p. 793-815.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function. / Hey-Mogensen, Martin; Gram, Martin; Jensen, Martin Borch; Lund, Michael Taulo; Hansen, Christina Neigaard; Scheibye-Knudsen, Morten; Bohr, Vilhelm A.; Dela, Flemming.

    In: The Journal of Physiology, Vol. 593, No. 17, 01.09.2015, p. 3991-4010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells. / Akbari, Mansour; Sykora, Peter; Bohr, Vilhelm A.

    In: Scientific Reports, Vol. 5, 12876 , 10.08.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The role of DNA base excision repair in brain homeostasis and disease. / Akbari, Mansour; Morevati, Marya; Croteau, Deborah; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 32, 08.2015, p. 172-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures. / Keijzers, Guido; Bohr, Vilhelm A; Juel Rasmussen, Lene.

    In: Bioscience Reports, Vol. 35, No. 3, e00206, 25.04.2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Protecting the mitochondrial powerhouse. / Scheibye-Knudsen, Morten; Fang, Evandro F.; Croteau, Deborah L.; Wilson, David M.; Bohr, Vilhelm A.

    In: Trends in Cell Biology, Vol. 25, No. 3, 01.03.2015, p. 158-170.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Loss of NEIL1 causes defects in olfactory function in mice. / Canugovi, Chandrika; Misiak, Magdalena; Scheibye-Knudsen, Morten; Croteau, Deborah L.; Mattson, Mark P.; Bohr, Vilhelm A.

    In: Neurobiology of Aging, Vol. 36, No. 2, 01.02.2015, p. 1007-1012.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance. / Maynard, S; Keijzers, G; Hansen, Åse Marie; Osler, M; Molbo, D; Bendix, L; Møller, P; Loft, S; Moreno-Villanueva, M; Bürkle, A; Hvitby, Christina Poulsen; Schurman, S H; Stevnsner, Tinna V.; Rasmussen, L J; Avlund, K; Bohr, V A.

    In: Acta Physiologica (Print), Vol. 213, No. 1, 01.2015, p. 156-170.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2014
  40. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli. / Bendtsen, Kristian Moss; Jensen, Martin Borch; May, Alfred; Rasmussen, Lene Juel; Trusina, Ala; Bohr, Vilhelm; Jensen, Mogens Høgh.

    In: European Biophysics Journal, Vol. 43, No. 10-11, 14.11.2014, p. 509-516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome. / Scheibye-Knudsen, Morten; Mitchell, Sarah J.; Fang, Evandro F.; Iyama, Teruaki; Ward, Theresa; Wang, James; Dunn, Christopher A.; Singh, Nagendra; Veith, Sebastian; Hasan-Olive, Md Mahdi; Mangerich, Aswin; Wilson, Mark A.; Mattson, Mark P.; Bergersen, Linda H.; Cogger, Victoria C.; Warren, Alessandra; Le Couteur, David G.; Moaddel, Ruin; Wilson, David M.; Croteau, Deborah L.; De Cabo, Rafael; Bohr, Vilhelm A.

    In: Cell Metabolism, Vol. 20, No. 5, 04.11.2014, p. 840-855.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    RECQ HELICASE RECQL4 PARTICIPATES IN NON-HOMOLOGOUS END JOINING AND INTERACTS WITH THE KU COMPLEX. / Shamanna, Raghavendra A; Singh, Dharmendra Kumar; Lu, Huiming; Mirey, Gladys; Keijzers, Guido; Salles, Bernard; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Carcinogenesis, Vol. 35, No. 11, 11.2014, p. 2415-2424.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The role of RecQ helicases in non-homologous end-joining. / Keijzers, Guido; Maynard, Scott; Shamanna, Raghavendra A; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Critical Reviews in Biochemistry and Molecular Biology, Vol. 49, No. 6, 11.2014, p. 463-472.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. / Fang, Evandro Fei; Scheibye-Knudsen, Morten; Brace, Lear E; Kassahun, Henok; SenGupta, Tanima; Nilsen, Hilde; Mitchell, James R; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Cell, Vol. 157, No. 4, 08.05.2014, p. 882-96.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair. / Akbari, Mansour; Keijzers, Guido; Maynard, Scott; Scheibye-Knudsen, Morten; Madsen, Claus Desler; Hickson, Ian D; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 16, 04.2014, p. 44-53.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity. / Aamann, Maria Diget; Hvitby, Christina Poulsen; Popuri, Venkateswarlu; Muftuoglu, Meltem; Lemminger, Lasse Pagh Brøgger; Skeby, Cecilie K; Keijzers, Guido; Ahn, Byungchan; Bjørås, Magnar; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Mechanisms of Ageing and Development, Vol. 135, 01.2014, p. 1-14.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Contribution of defective mitophagy to the neurodegeneration in DNA repair-deficient disorders. / Scheibye-Knudsen, Morten; Fang, Evandro Fei; Croteau, Deborah L.; Bohr, Vilhelm A.

    In: Autophagy, Vol. 10, No. 8, 2014, p. 1468-1469.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis. / Li, Xiaolin; Fang, Evandro Fei; Scheibye-Knudsen, Morten; Cui, Honghua; Qiu, Lu; Li, Jian; He, Yuping; Huang, Jing; Bohr, Vilhelm A.; Ng, Tzi Bun; Guo, Hongwei.

    In: Scientific Reports, Vol. 4, 6434, 2014.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2013
  50. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells. / Maynard, Scott; Keijzers, Guido; Gram, Martin; Madsen, Claus Desler; Bendix, Laila; Budtz-Jørgensen, Esben; Molbo, Drude; Croteau, Deborah L; Osler, Merete; Stevnsner, Tinna V.; Rasmussen, Lene Juel; Dela, Flemming; Avlund, Kirsten; Bohr, Vilhelm A.

    In: Aging, 30.11.2013, p. 850-864.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    DNA damage response, bioenergetics, and neurological disease : the challenge of maintaining brain health in an aging human population. / Rasmussen, Lene Juel; Shiloh, Yosef; Bergersen, Linda H; Sander, Miriam; Bohr, Vilhelm A; Tønjum, Tone.

    In: Mechanisms of Ageing and Development, Vol. 134, No. 10, 10.2013, p. 427-33.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Modulation of DNA base excision repair during neuronal differentiation. / Sykora, Peter; Yang, Jenq-Lin; Ferrarelli, Leslie K; Tian, Jingyan; Tadokoro, Takashi; Kulkarni, Avanti; Weissman, Lior; Keijzers, Guido; Wilson, David M; Mattson, Mark P; Bohr, Vilhelm A.

    In: Neurobiology of Aging, Vol. 34, No. 7, 07.2013, p. 1717-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells. / Nguyen, Giang Huong; Dexheimer, Thomas S; Rosenthal, Andrew S; Chu, Wai Kit; Singh, Dharmendra Kumar; Mosedale, Georgina; Bachrati, Csanád Z; Schultz, Lena; Sakurai, Masaaki; Savitsky, Pavel; Abu, Mika; McHugh, Peter J; Bohr, Vilhelm A; Harris, Curtis C; Jadhav, Ajit; Gileadi, Opher; Maloney, David J; Simeonov, Anton; Hickson, Ian D.

    In: Chemistry & Biology, Vol. 20, No. 1, 24.01.2013, p. 55-62.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2012
  55. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients. / Jensen, Martin Borch; Dunn, Christopher A; Keijzers, Guido; Kulikowicz, Tomasz; Rasmussen, Lene Juel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Aging, Vol. 4, No. 11, 11.2012, p. 790-802.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy. / Scheibye-Knudsen, Morten; Ramamoorthy, Mahesh; Sykora, Peter; Maynard, Scott; Lin, Ping-Chang; Minor, Robin K; Wilson, David M; Cooper, Marcus; Spencer, Richard; de Cabo, Rafael; Croteau, Deborah L; Bohr, Vilhelm A.

    In: The Journal of Experimental Medicine, Vol. 209, No. 4, 04.2012, p. 855-69.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. / Andersen, Sofie Dabros; Keijzers, Guido; Rampakakis, Emmanouil; Engels, Kim; Luhn, Patricia; El-Shemerly, Mahmoud; Nielsen, Finn Cilius; Du, Yuhong; May, Alfred; Bohr, Vilhelm A; Ferrari, Stefano; Zannis-Hadjopoulos, Maria; Fu, Haian; Rasmussen, Lene Juel.

    In: D N A Repair, Vol. 11, No. 3, 03.2012, p. 267-77.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. / Croteau, Deborah L; Rossi, Marie L; Canugovi, Chandrika; Tian, Jane; Sykora, Peter; Ramamoorthy, Mahesh; Wang, Zheng Ming; Singh, Dharmendra Kumar; Akbari, Mansour; Kasiviswanathan, Rajesh; Copeland, William C; Bohr, Vilhelm A.

    In: Aging Cell, Vol. 11, No. 3, 2012, p. 456-66.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. 2011
  60. Published

    Aging, longevity and health. / Rasmussen, Lene Juel; Sander, Miriam; Wewer, Ulla M.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, 23.07.2011, p. 522-32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein. / Bernier, Michel; Paul, Rajib K; Martin-Montalvo, Alejandro; Scheibye-Knudsen, Morten; Song, Shaoming; He, Hua-Jun; Armour, Sean M; Hubbard, Basil P; Bohr, Vilhelm A; Wang, Lili; Zong, Yaping; Sinclair, David A; de Cabo, Rafael.

    In: The Journal of Biological Chemistry, Vol. 286, No. 22, 03.06.2011, p. 19270-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Aprataxin localizes to mitochondria and preserves mitochondrial function. / Sykora, Peter; Croteau, Deborah L; Bohr, Vilhelm A; Wilson, David M.

    In: Proceedings of the National Academy of Sciences USA (PNAS), Vol. 108, No. 18, 03.05.2011, p. 7437-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    DNA repair deficiency in neurodegeneration. / Jeppesen, Dennis Kjølhede; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Progress in Neurobiology, Vol. 94, No. 2, 30.04.2011, p. 166-200.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. / Bacolla, Albino; Wang, Guliang; Jain, Aklank; Chuzhanova, Nadia A; Cer, Regina Z; Collins, Jack R; Cooper, David N; Bohr, Vilhelm A; Vasquez, Karen M.

    In: The Journal of Biological Chemistry, Vol. 286, No. 12, 25.03.2011, p. 10017-26.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Proteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples. / Lachapelle, Sophie; Gagné, Jean-Philippe; Garand, Chantal; Desbiens, Myriam; Coulombe, Yan; Bohr, Vilhelm A; Hendzel, Michael J; Masson, Jean-Yves; Poirier, Guy G; Lebel, Michel.

    In: Journal of Proteome Research, Vol. 10, No. 3, 04.03.2011, p. 1216-27.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions. / Liu, Dong; Croteau, Deborah L; Souza-Pinto, Nadja; Pitta, Michael; Tian, Jingyan; Wu, Christopher; Jiang, Haiyang; Mustafa, Khadija; Keijzers, Guido; Bohr, Vilhelm; Mattson, Mark P.

    In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 2, 02.2011, p. 680-692.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. / Liberti, Sascha E; Andersen, Sofie Dabros; Wang, Jing; May, Alfred; Miron, Simona; Perderiset, Mylene; Keijzers, Guido; Nielsen, Finn C; Charbonnier, Jean-Baptiste; Bohr, Vilhelm A; Rasmussen, Lene J.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 73-86.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. / Rhee, David B; Ghosh, Avik; Lu, Jian; Bohr, Vilhelm A; Liu, Yie.

    In: DNA Repair, Vol. 10, No. 1, 02.01.2011, p. 34-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Metabolism, genomics, and DNA repair in the mouse aging liver. / Lebel, Michel; de Souza-Pinto, Nadja C; Bohr, Vilhelm A.

    In: Current Gerontology and Geriatrics Research, Vol. 2011, 01.01.2011, p. 859415.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. 2010
  71. Published

    Base excision repair activities differ in human lung cancer cells and corresponding normal controls. / Karahalil, Bensu; Bohr, Vilhelm A; De Souza-Pinto, Nadja C.

    In: Anticancer Research, Vol. 30, No. 12, 01.12.2010, p. 4963-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. / Soerensen, Mette; Dato, Serena; Christensen, Kaare; McGue, Matt; Stevnsner, Tinna V.; Bohr, Vilhelm A; Christiansen, Lene.

    In: Aging Cell, Vol. 9, No. 6, 01.12.2010, p. 1010-7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    DNA Repair and the Accumulation of Oxidatively Damaged DNA Are Affected by Fruit Intake in Mice. / Croteau, Deborah L; de Souza-Pinto, Nadja C; Harboe, Charlotte; Keijzers, Guido; Zhang, Yongqing; Becker, Kevin; Sheng, Shan; Bohr, Vilhelm.

    In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Vol. 65, No. 12, 12.2010, p. 1300-1311.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Human RecQL4 helicase plays critical roles in prostate carcinogenesis. / Su, Yanrong; Meador, Jarah A; Calaf, Gloria M; Proietti De-Santis, Luca; Zhao, Yongliang; Bohr, Vilhelm A; Balajee, Adayabalam S.

    In: Cancer Research, Vol. 70, No. 22, 15.11.2010, p. 9207-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    The mitochondrial transcription factor A functions in mitochondrial base excision repair. / Canugovi, Chandrika; Maynard, Scott; Bayne, Anne-Cécile V; Sykora, Peter; Tian, Jingyan; de Souza-Pinto, Nadja C; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 10, 05.10.2010, p. 1080-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Telomerer--begyndelsen og enden. / Bohr, Vilhelm A.

    In: Ugeskrift for Laeger, Vol. 172, No. 40, 04.10.2010, p. 2744.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease. / Diaz, Ricardo Gredilla; Weissman, Lior; Yang, Jenq-Lin; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Neurobiology of Aging, 12.08.2010.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. / Berquist, Brian R; Singh, Dharmendra Kumar; Fan, Jinshui; Kim, Daemyung; Gillenwater, Elizabeth; Kulkarni, Avanti; Bohr, Vilhelm A; Ackerman, Eric J; Tomkinson, Alan E; Wilson, David M.

    In: Nucleic Acids Symposium Series, Vol. 38, No. 15, 01.08.2010, p. 5023-35.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Mitochondrial DNA repair and association with aging--an update. / Diaz, Ricardo Gredilla; Bohr, Vilhelm A; Stevnsner, Tinna V.

    In: Experimental Gerontology, Vol. 45, No. 7-8, 01.08.2010, p. 478-88.

    Research output: Contribution to journalReviewResearchpeer-review

  80. Published

    Mitochondrial base excision repair assays. / Maynard, Scott; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten; Bohr, Vilhelm A.

    In: Methods, Vol. 51, No. 4, 01.08.2010, p. 416-25.

    Research output: Contribution to journalReviewResearchpeer-review

  81. Published

    Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. / Aamann, Maria Diget; Sorensen, Martin M; Hvitby, Christina Poulsen; Berquist, Brian R; Muftuoglu, Meltem; Tian, Jingyan; de Souza-Pinto, Nadja C; Scheibye-Knudsen, Morten; Wilson, David M; Stevnsner, Tinna V.; Bohr, Vilhelm A.

    In: The FASEB Journal, Vol. 24, No. 7, 01.07.2010, p. 2334-46.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. / Rossi, Marie L; Ghosh, Avik K; Kulikowicz, Tomasz; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 7, 01.07.2010, p. 796-804.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Mitochondria and aging. / Prolla, Tomas A; Bohr, Vilhelm A; de Souza-Pinto, Nadja C.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 07.2010, p. 449-50.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases. / Popuri, Venkateswarlu; Croteau, Deborah L; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 6, 04.06.2010, p. 636-42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    The involvement of human RECQL4 in DNA double-strand break repair. / Singh, Dharmendra Kumar; Karmakar, Parimal; Aamann, Maria Diget; Schurman, Shepherd H; May, Alfred; Croteau, Deborah L; Burks, Lynnette; Plon, Sharon E; Bohr, Vilhelm A.

    In: Aging Cell, Vol. 9, No. 3, 01.06.2010, p. 358-71.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loops. / Kusumoto-Matsuo, Rika; Opresko, Patricia L; Ramsden, Dale; Tahara, Hidetoshi; Bohr, Vilhelm A.

    In: Aging, Vol. 2, No. 5, 01.05.2010, p. 274-84.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Human RECQL5beta stimulates flap endonuclease 1. / Speina, Elzbieta; Dawut, Lale; Hedayati, Mohammad; Wang, Zhengming; May, Alfred; Schwendener, Sybille; Janscak, Pavel; Croteau, Deborah L; Bohr, Vilhelm A.

    In: Nucleic Acids Symposium Series, Vol. 38, No. 9, 01.05.2010, p. 2904-16.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Nutrition and aging. / Cheng, Wen-Hsing; Bohr, Vilhelm A; de Cabo, Rafael.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 4, 01.04.2010, p. 223-4.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Depletion of WRN protein causes RACK1 to activate several protein kinase C isoforms. / Massip, L; Garand, C; Labbé, A; Perreault, E; Turaga, R V N; Bohr, V A; Lebel, M.

    In: Oncogene, Vol. 29, No. 10, 11.03.2010, p. 1486-97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Roles of Werner syndrome protein in protection of genome integrity. / Rossi, Marie L; Ghosh, Avik K; Bohr, Vilhelm A.

    In: DNA Repair, Vol. 9, No. 3, 02.03.2010, p. 331-44.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Impact papers on aging in 2009. / Blagosklonny, Mikhail V; Campisi, Judy; Sinclair, David A; Bartke, Andrzej; Blasco, Maria A; Bonner, William M; Bohr, Vilhelm A; Brosh, Robert M; Brunet, Anne; Depinho, Ronald A; Donehower, Lawrence A; Finch, Caleb E; Finkel, Toren; Gorospe, Myriam; Gudkov, Andrei V; Hall, Michael N; Hekimi, Siegfried; Helfand, Stephen L; Karlseder, Jan; Kenyon, Cynthia; Kroemer, Guido; Longo, Valter; Nussenzweig, Andre; Osiewacz, Heinz D; Peeper, Daniel S; Rando, Thomas A; Rudolph, K Lenhard; Sassone-Corsi, Paolo; Serrano, Manuel; Sharpless, Norman E; Skulachev, Vladimir P; Tilly, Jonathan L; Tower, John; Verdin, Eric; Vijg, Jan.

    In: Aging, Vol. 2, No. 3, 01.03.2010, p. 111-21.

    Research output: Contribution to journalReviewResearch

  92. Published

    Earl R. Stadtman. / Levine, Rodney L; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 1, 01.01.2010, p. 1.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Mitochondrial helicases and mitochondrial genome maintenance. / de Souza-Pinto, Nadja C; Aamann, Maria Diget; Kulikowicz, Tomasz; Stevnsner, Tinna V.; Bohr, Vilhelm A.

    In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 2010, p. 503-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. / Yang, Jenq-Lin; Tadokoro, Takashi; Keijzers, Guido; Mattson, Mark P; Bohr, Vilhelm.

    In: Journal of Biological Chemistry, Vol. 285, No. 36, 2010, p. 28191-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. 2009
  96. Published

    The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. / de Souza-Pinto, Nadja C; Maynard, Scott; Hashiguchi, Kazunari; Hu, Jingping; Muftuoglu, Meltem; Bohr, Vilhelm A.

    In: Molecular and Cellular Biology, Vol. 29, No. 16, 08.2009, p. 4441-54.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase. / Muftuoglu, Meltem; de Souza-Pinto, Nadja C; Dogan, Arin; Aamann, Maria; Stevnsner, Tinna; Rybanska, Ivana; Kirkali, Güldal; Dizdaroglu, Miral; Bohr, Vilhelm A.

    In: Journal of Biological Chemistry, Vol. 284, No. 14, 04.2009, p. 9270-9.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Base excision repair of oxidative DNA damage and association with cancer and aging. / Maynard, Scott; Schurman, Shepherd H; Harboe, Charlotte; de Souza-Pinto, Nadja C; Bohr, Vilhelm A.

    In: Carcinogenesis, Vol. 30, No. 1, 01.01.2009, p. 2-10.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. / McCord, Ronald A; Michishita, Eriko; Hong, Tao; Berber, Elisabeth; Boxer, Lisa D; Kusumoto, Rika; Guan, Shenheng; Shi, Xiaobing; Gozani, Or; Burlingame, Alma L; Bohr, Vilhelm A; Chua, Katrin F.

    In: Aging, Vol. 1, No. 1, 01.01.2009, p. 109-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. 2008
  101. Published

    Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. / Maynard, Scott; Swistowska, Anna Maria; Lee, Jae Wan; Liu, Ying; Liu, Su-Ting; Da Cruz, Alexandre Bettencourt; Rao, Mahendra; de Souza-Pinto, Nadja C; Zeng, Xianmin; Bohr, Vilhelm A.

    In: Stem Cells, Vol. 26, No. 9, 01.09.2008, p. 2266-74.

    Research output: Contribution to journalJournal articleResearchpeer-review

  102. Published

    Acetylation regulates WRN catalytic activities and affects base excision DNA repair. / Muftuoglu, Meltem; Kusumoto, Rika; Speina, Elzbieta; Beck, Gad; Cheng, Wen-Hsing; Bohr, Vilhelm A.

    In: P L o S One, Vol. 3, No. 4, 01.2008, p. e1918.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4975983